Evidence map›Paper›PMID 31263381›Full record

ArticleMediators of inflammation2019

Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor.

Mohamed A Morsy, Snehal S Patel, Azza A K El-Sheikh, Jignasa K Savjani, Anroop B Nair, Jigar N Shah, Katharigatta N Venugopala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Frontiers in pharmacology · 2021
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Mohamed A MorsyDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0002-6752-9094
Snehal S PatelDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382 481, India.ORCID 0000-0002-5002-7530
Azza A K El-SheikhDepartment of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, Egypt.ORCID 0000-0003-3726-0386
Jignasa K SavjaniDepartment of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382 481, India.
Anroop B NairDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Jigar N ShahDepartment of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382 481, India.
Katharigatta N VenugopalaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0003-0680-1549
Nirma University · INKing Faisal University · SADurban University of Technology · ZAPrincess Nourah bint Abdulrahman University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the usefulness of glucocorticoids, they may cause hazardous side effects that limit their use. Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone, boswellic acid, withaferin A, and diosgenin with the classical glucocorticoid, fluticasone. This was approached both

Indexed as

AnimalsAnti-Inflammatory AgentsCroton OilDiosgeninEar DiseasesEdemaEnzyme-Linked Immunosorbent AssayGlycyrrhetinic AcidInflammationInterleukin-6MiceMolecular Docking SimulationPhytosterolsPregnenedionesRatsReceptors, GlucocorticoidAnti-Inflammatory Agentsboswellic acidCroton OilDiosgeninGlycyrrhetinic AcidInterleukin-6Phytosterolspregna-4,17-diene-3,16-dionePregnenedionesReceptors, GlucocorticoidTriterpenesTumor Necrosis Factor-alphawithaferin AWithanolides

Identifiers

PMID31263381
PMCPMC6556784
OpenAlexW2947385530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.