Evidence map›Paper›PMID 31263248›Full record

Observational studyInternational journal of impotence research2020

Nomegestrol acetate/17beta-estradiol does not negatively alter the vascular resistance of clitoral arteries: a prospective, exploratory study.

Irene Scavello, Elisa Maseroli, Vincenza Di Stasi, Sarah Cipriani, Nunzia Verde, Angela Magini, Mario Maggi, Linda Vignozzi

2 registry-linked trialsAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of impotence research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02613039 phase4completednot on this map

Study on the Effect of Combined Oral Contraceptive Therapy on Female Sexuality, Body Image and Mental Health

TypeinterventionalSponsorUniversity of FlorenceRan2015 to 2019Enrolled10ConditionsContraceptive Usage, Sexual Behavior, Mental Health Wellness 1ArmsCombined Estrogen-Progestin Oral Contraceptives
NCT04336891 completednot on this map

Pilot Retrospective Study on the Effect of Testosterone Treatment on Clitoral Arteries' Hemodynamic Parameters.

TypeobservationalSponsorUniversity of FlorenceRan2019 to 2020Enrolled81ConditionsHypoactive Sexual Desire Disorder, Vulvovaginal Disease, Menopause Related Conditions, Dyspareunia (Female Excluding Psychogenic)ArmsTestosterone gel, Estradiol ovules, Moisturizer, Testosterone gel + Estradiol ovules
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Irene Scavello *Department of Experimental, Clinical, and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Elisa Maseroli *Department of Experimental, Clinical, and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Vincenza Di StasiDepartment of Experimental, Clinical, and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Sarah CiprianiDepartment of Experimental, Clinical, and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Nunzia VerdeMedicine and Surgery, Section of Endocrinology, Federico II, University of Naples, Naples, Italy.
Angela MaginiDepartment of Experimental, Clinical, and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Mario MaggiDepartment of Experimental, Clinical, and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Linda VignozziDepartment of Experimental, Clinical, and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy. linda.vignozzi@unifi.it.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of nomegestrol acetate/estradiol (NOMAC/E2) on clitoral and uterine vascularization has never been evaluated. We aimed to investigate, in women consulting for contraceptive needs, the possible changes in clitoral and uterine arteries hemodynamic parameters after 6 months treatment with NOMAC/E2 as compared with other hormonal contraceptives (HCs). In this observational, prospective pilot study, ten women were enrolled. Color Doppler ultrasound was performed on the clitoral and uterine arteries at baseline and after 6 months treatment with NOMAC/E2 (n = 5) or other HCs (n = 5). NOMAC/E2 did not exert any significant effect on clitoral vascular resistance expressed by the pulsatility index (PI); conversely, treatment with other HCs significantly increased this parameter (p = 0.04). The change in clitoral PI between the two groups retained a statistically significant difference even after adjusting for age. In the NOMAC/E2 group, at follow-up, uterine artery PI and acceleration were significantly reduced (p = 0.04), whereas no significant differences were observed in the HCs group; however, the change in uterine artery parameters did not differ significantly between the two groups. NOMAC/E2, differently from other COCs, does not negatively alter the vascular resistance of clitoral arteries and appears as a good contraceptive choice to protect both cardiovascular and sexual health.

Indexed as

Vascular ResistanceAdultClitorisContraceptives, Oral, HormonalEstradiolFemaleHumansItalyLinear ModelsMegestrolNorpregnadienesPilot ProjectsProspective StudiesUltrasonography, Doppler, ColorUterine ArteryYoung AdultContraceptives, Oral, HormonalEstradiolMegestrolnomegestrol acetateNorpregnadienes

Identifiers

PMID31263248
OpenAlexW2953951083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.