Evidence map›Paper›PMID 31263155›Full record

ArticleScientific reports2019

Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.

Zheng Chen, Ruiwei Jiang, Mengxia Chen, Jiashuo Zheng, Min Chen, Nady Braidy, Shunli Liu, Guohao Liu, Zaitunamu Maimaitiming, Tianqi Shen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

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  15. The biology of mammalian multi-copper ferroxidases.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Zheng ChenJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Ruiwei JiangJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0001-5857-8540
Mengxia ChenJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Jiashuo ZhengJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Min ChenJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Nady BraidyInstitute of Virology, Wenzhou University, Wenzhou, China.
Shunli LiuJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Guohao LiuJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Zaitunamu MaimaitimingJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Tianqi ShenJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China.
Joshua L DunaiefFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Christopher D VulpeCenter for Environmental and Human Toxicology, Department of Physiological Sciences, University of Florida, Gainesville, FL, USA.
Gregory J AndersonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Huijun ChenJiangsu Key Laboratory of Molecular Medicine,, Medical School of Nanjing University, Nanjing, China. hjchen@nju.edu.cn.
Nanjing University · CNWenzhou University · CNNanjing Medical University · CNPenn Presbyterian Medical Center · USQIMR Berghofer Medical Research Institute · AUUniversity of Florida · USXiamen University · CN

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
NEI NIH HHS P30 EY001583
6 · The paper itself

Abstract

Accumulation of iron has been associated with the pathobiology of various disorders of the central nervous system. Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in multiple brain regions and that this was paralleled by increased oxidative damage and deficits in cognition and memory. In this study, we enriched astrocytes and oligodendrocytes from the cerebral cortex of neonatal wild-type (WT), Heph KO and Cp KO mice. We demonstrated that Heph is highly expressed in oligodendrocytes, while Cp is mainly expressed in astrocytes. Iron efflux was impaired in Cp KO astrocytes and Heph KO oligodendrocytes and was associated with increased oxidative stress. The expression of Heph, Cp, and other iron-related genes was examined in astrocytes and oligodendrocytes both with and without iron treatment. Interestingly, we found that the expression of the mRNA encoding ferroportin 1, a transmembrane protein that cooperates with CP and HEPH to export iron from cells, was positively correlated with Cp expression in astrocytes, and with Heph expression in oligodendrocytes. Our findings collectively demonstrate that HEPH and CP are important for the prevention of glial iron accumulation and thus may be protective against oxidative damage.

Indexed as

Oxidative StressAnimalsAstrocytesCeruloplasminIronMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutOligodendrogliaCeruloplasminHeph protein, mouseIronMembrane Proteins

Identifiers

PMID31263155
PMCPMC6603037
OpenAlexW2954627035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.