Evidence map›Paper›PMID 31263146›Full record

ArticleScientific reports2019

BIN1 favors the spreading of Tau via extracellular vesicles.

Andrea Crotti, Hameetha Rajamohamend Sait, Kathleen M McAvoy, Karol Estrada, Ayla Ergun, Suzanne Szak, Galina Marsh, Luke Jandreski, Michael Peterson, Taylor L Reynolds and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 4 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 4 syntheses or guidelines pooled it, 171 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Article
  7. Article
  8. Article
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  10. Article
  11. Extracellular Vesicles in Tauopathies: Mechanisms and Applications.International journal of molecular sciences · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  18. Review
  19. Article
  20. Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Andrea CrottiBiogen, 225 Binney St., Cambridge, MA, 02142, USA. andrea.crotti@astellas.com.ORCID http://orcid.org/0000-0002-9421-4370
Hameetha Rajamohamend SaitBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Kathleen M McAvoyBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Karol EstradaBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Ayla ErgunFulcrum Therapeutics, 26 Landsdowne St, Cambridge, MA, 02139, USA.
Suzanne SzakBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Galina MarshBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Luke JandreskiBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Michael PetersonBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Taylor L ReynoldsBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Isin Dalkilic-LiddleBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Andrew CameronBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Ellen Cahir-McFarlandBiogen, 225 Binney St., Cambridge, MA, 02142, USA.
Richard M RansohoffThird Rock Ventures, 29 Newbury Street, Suite 30, Boston, MA, 02116, USA.ORCID http://orcid.org/0000-0003-0175-6910
Biogen (United States) · USFulcrum Therapeutics (United States) · USNewbury College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite Bridging INtegrator 1 (BIN1) being the second most statistically-significant locus associated to Late Onset Alzheimer's Disease, its role in disease pathogenesis remains to be clarified. As reports suggest a link between BIN1, Tau and extracellular vesicles, we investigated whether BIN1 could affect Tau spreading via exosomes secretion. We observed that BIN1-associated Tau-containing extracellular vesicles purified from cerebrospinal fluid of AD-affected individuals are seeding-competent. We showed that BIN1 over-expression promotes the release of Tau via extracellular vesicles in vitro as well as exacerbation of Tau pathology in vivo in PS19 mice. Genetic deletion of Bin1 from microglia resulted in reduction of Tau secretion via extracellular vesicles in vitro, and in decrease of Tau spreading in vivo in male, but not female, mice, in the context of PS19 background. Interestingly, ablation of Bin1 in microglia of male mice resulted in significant reduction in the expression of heat-shock proteins, previously implicated in Tau proteostasis. These observations suggest that BIN1 could contribute to the progression of AD-related Tau pathology by altering Tau clearance and promoting release of Tau-enriched extracellular vesicles by microglia.

Indexed as

Adaptor Proteins, Signal TransducingAlzheimer DiseaseAnimalsExtracellular VesiclesFemaleGene Expression RegulationHEK293 CellsHumansMaleMiceMice, TransgenicMicrogliaNerve Tissue ProteinsNuclear ProteinsProteostasisSex CharacteristicsAdaptor Proteins, Signal TransducingBIN1 protein, humanBin1 protein, mouseMAPT protein, humanMapt protein, mouseNerve Tissue ProteinsNuclear Proteinstau ProteinsTumor Suppressor Proteins

Identifiers

PMID31263146
PMCPMC6603165
OpenAlexW2954072698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.