ArticleScientific reports2019
Boundary effects of expectation in human pain perception.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans.Pain · 2026Article
- Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency.eLife · 2026Article
- Temporal predictions shape somatosensory perception.Nature communications · 2026Article
- Nocebo effects are stronger and more persistent than placebo effects in healthy individuals.eLife · 2025Article
- Dynamic learning of the meaning of information changes pain perception.Scientific reports · 2025Article
- Two pathways to resolve relational inconsistencies.Scientific reports · 2025Article
- Expectation generation and its effect on subsequent pain and visual perception.PLoS computational biology · 2025Article
- Adverse Childhood Experiences (ACEs) in Specific Vulnerable Developmental Periods Can Increase the Likelihood of Chronic Pain in Adulthood-Results from a Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2025Article
- Physiological framework for non-invasive detection and objective nociception activity in communicative patients: a pilot case study.Frontiers in physiology · 2025Article
- How the magnitude and precision of pain predictions shape pain experiences.European journal of pain (London, England) · 2025Article
- Statistical learning shapes pain perception and prediction independently of external cues.eLife · 2024Article
- SOMAScience: A Novel Platform for Multidimensional, Longitudinal Pain Assessment.JMIR mHealth and uHealth · 2024Article
- The Placebo Effect in Psychosis: Why It Matters and How to Measure It.Biological psychiatry global open science · 2023Review
- A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing.Scientific reports · 2023Article
- A virtual experimenter does not increase placebo hypoalgesia when delivering an interactive expectancy manipulation.Scientific reports · 2020Article
- Hyperalgesia and Reduced Offset Analgesia During Spinal Anesthesia.Journal of pain research · 2020Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Perception of sensory stimulation is influenced by numerous psychological variables. One example is placebo analgesia, where expecting low pain causes a painful stimulus to feel less painful. Yet, because pain evolved to signal threats to survival, it should be maladaptive for highly-erroneous expectations to yield unrealistic pain experiences. Therefore, we hypothesised that a cue followed by a highly discrepant stimulus intensity, which generates a large prediction error, will have a weaker influence on the perception of that stimulus. To test this hypothesis we collected two independent pain-cueing datasets. The second dataset and the analysis plan were preregistered ( https://osf.io/5r6z7/ ). Regression modelling revealed that reported pain intensities were best explained by a quartic polynomial model of the prediction error. The results indicated that the influence of cues on perceived pain decreased when stimulus intensity was very different from expectations, suggesting that prediction error size has an immediate functional role in pain perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.