Evidence map›Paper›PMID 31263131›Full record

ArticleScientific reports2019

Major changes in chromosomal somy, gene expression and gene dosage driven by Sb

Luz H Patino, Hideo Imamura, Lissa Cruz-Saavedra, Paula Pavia, Carlos Muskus, Claudia Méndez, Jean Claude Dujardin, Juan David Ramírez

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 64 citations in OpenAlex.

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  15. Nitric Oxide Resistance inAntioxidants (Basel, Switzerland) · 2022
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  16. Impact of Genetic Diversity and Genome Plasticity ofFrontiers in cellular and infection microbiology · 2022
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  17. Characterization of Differentially Abundant Proteins AmongFrontiers in cellular and infection microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Luz H PatinoGrupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.
Hideo ImamuraMolecular Parasitology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-3282-1319
Lissa Cruz-SaavedraGrupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.
Paula PaviaUnidad de Investigación Científica, Subdirección de Docencia e Investigación, Hospital Militar Central, Bogotá, Colombia.
Carlos MuskusPrograma de Estudio y Control de Enfermedades Tropicales (PECET), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Claudia MéndezDirección de Sanidad Militar, Ejercito Nacional de Colombia, Bogotá, Colombia.
Jean Claude DujardinMolecular Parasitology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Juan David RamírezGrupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia. juand.ramirez@urosario.edu.co.
Universidad del Rosario · COHospital Militar Central · COInstituut voor Tropische Geneeskunde · BEUniversidad de Antioquia · COUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmania braziliensis and Leishmania panamensis are two species clinically and epidemiologically important, among others because of their relative resistance to first-line drugs (antimonials). The precise mechanism underlying the ability of these species to survive antimony treatment remains unknown. Therefore, elucidating the pathways mediating drug resistance is essential. We herein experimentally selected resistance to trivalent antimony (Sb

Indexed as

ChromosomesGene DosageGenes, ProtozoanLeishmania braziliensisAntimonyGene Expression RegulationSpecies SpecificityAntimony

Identifiers

PMID31263131
PMCPMC6603004
OpenAlexW2955084268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.