Evidence map›Paper›PMID 31263116›Full record

ArticleScientific reports2019

Repeatability of Multiparametric Prostate MRI Radiomics Features.

Michael Schwier, Joost van Griethuysen, Mark G Vangel, Steve Pieper, Sharon Peled, Clare Tempany, Hugo J W L Aerts, Ron Kikinis, Fiona M Fennessy, Andriy Fedorov

Registry-linked trialAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05024162 (Can Magnetic Resonance Imaging of the Prostate Combined With a Radiomics Evaluation Determine the Invasive Capacity of a Tumour), which is not on this map. Cited by 133 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05024162 narecruitingnot on this mapstarted 2022, after this paper: background citation

Can Magnetic Resonance Imaging of the Prostate Combined With a Radiomics Evaluation Determine the Invasive Capacity of a Tumour (Can MRI-PREDICT)

TypeinterventionalSponsorNova Scotia Health AuthorityRan2022 to 2025Enrolled60ConditionsProstate CancerArmsMRT Accuracy, MRT Stability
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Reproducibility and interpretability in radiomics: a critical assessmentDiagnostic and interventional radiology (Ankara, Turkey) · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael SchwierBrigham and Women's Hospital, Boston, MA, USA.
Joost van GriethuysenNetherlands Cancer Institute Maastricht University, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0003-0447-0918
Mark G VangelHarvard Medical School, Boston, MA, USA.
Steve PieperIsomics, Inc, Cambridge, MA, USA.
Sharon PeledBrigham and Women's Hospital, Boston, MA, USA.
Clare TempanyBrigham and Women's Hospital, Boston, MA, USA.
Hugo J W L AertsHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2122-2003
Ron KikinisBrigham and Women's Hospital, Boston, MA, USA.
Fiona M FennessyBrigham and Women's Hospital, Boston, MA, USA.
Andriy FedorovBrigham and Women's Hospital, Boston, MA, USA. andrey.fedorov@gmail.com.ORCID http://orcid.org/0000-0003-4806-9413

Funding

Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
Quantitative Image Informatics for Cancer Research (QIICR)U24CA180918 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEDOROV, ANDRIY, KIKINIS, RON · 2013 to 2017
$4.0M
Quantitative Radiomics System Decoding the Tumor PhenotypeU24CA194354 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.5M
Genotype and Imaging Phenotype Biomarkers in Lung CancerU01CA190234 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.3M
Quantitiative MRI of prostate cancer as a biomarker and guide for treatmentU01CA151261 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FENNESSY, FIONA · 2010 to 2014
$1.8M
NCI NIH HHS U01 CA151261NCI NIH HHS U01 CA190234NCI NIH HHS U24 CA180918NCI NIH HHS U24 CA194354NIBIB NIH HHS P41 EB015898
6 · The paper itself

Abstract

In this study we assessed the repeatability of radiomics features on small prostate tumors using test-retest Multiparametric Magnetic Resonance Imaging (mpMRI). The premise of radiomics is that quantitative image-based features can serve as biomarkers for detecting and characterizing disease. For such biomarkers to be useful, repeatability is a basic requirement, meaning its value must remain stable between two scans, if the conditions remain stable. We investigated repeatability of radiomics features under various preprocessing and extraction configurations including various image normalization schemes, different image pre-filtering, and different bin widths for image discretization. Although we found many radiomics features and preprocessing combinations with high repeatability (Intraclass Correlation Coefficient > 0.85), our results indicate that overall the repeatability is highly sensitive to the processing parameters. Neither image normalization, using a variety of approaches, nor the use of pre-filtering options resulted in consistent improvements in repeatability. We urge caution when interpreting radiomics features and advise paying close attention to the processing configuration details of reported results. Furthermore, we advocate reporting all processing details in radiomics studies and strongly recommend the use of open source implementations.

Indexed as

Biomarkers, TumorHumansImage Processing, Computer-AssistedMaleMultiparametric Magnetic Resonance ImagingProstateProstatic NeoplasmsReproducibility of ResultsBiomarkers, Tumor

Identifiers

PMID31263116
PMCPMC6602944

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.