ArticleNature communications2019
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Lumbar spinal Shox2 interneurons receive monosynaptic excitatory input from the lateral paragigantocellular nucleus in mouse.iScience · 2026Article
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- A probabilistic model of behavioural emergence from general anaesthesia in mice.British journal of anaesthesia · 2025Article
- Modeling Emotional Arousal With Turbulence Measured by EEG.Psychophysiology · 2025Article
- Cortical signatures linked to behavior quantitatively track arousal levels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- New Step in Understanding the Pathogenetic Mechanism of Sudden Infant Death Syndrome: Involvement of the Pontine Reticular Gigantocellular Nucleus.International journal of molecular sciences · 2024Article
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Review
- Neuromodulatory control of complex adaptive dynamics in the brain.Interface focus · 2023Review
- Article
- Weakly Correlated Local Cortical State Switches under Anesthesia Lead to Strongly Correlated Global States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Prefrontal cortex as a key node in arousal circuitry.Trends in neurosciences · 2022Review
- General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons.Neuron · 2022Article
- Historical and Modern Evidence for the Role of Reward Circuitry in Emergence.Anesthesiology · 2022Review
- Deep brain stimulation of the thalamus restores signatures of consciousness in a nonhuman primate model.Science advances · 2022Article
- Lateralisation of subcortical functional connectivity during and after general anaesthesia.British journal of anaesthesia · 2022Article
- Kv2.1 expression in giant reticular neurons of the postnatal mouse brain.Journal of chemical neuroanatomy · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Multiple areas within the reticular activating system (RAS) can hasten awakening from sleep or light planes of anesthesia. However, stimulation in individual sites has shown limited recovery from deep global suppression of brain activity, such as coma. Here we identify a subset of RAS neurons within the anterior portion of nucleus gigantocellularis (aNGC) capable of producing a high degree of awakening represented by a broad high frequency cortical reactivation associated with organized movements and behavioral reactivity to the environment from two different models of deep pharmacologically-induced coma (PIC): isoflurane (1.25%-1.5%) and induced hypoglycemic coma. Activating aNGC neurons triggered awakening by recruiting cholinergic, noradrenergic, and glutamatergic arousal pathways. In summary, we identify an evolutionarily conserved population of RAS neurons, which broadly restore cerebral cortical activation and motor behavior in rodents through the coordinated activation of multiple arousal-promoting circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.