ArticleCancer discovery2019
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
What it found
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Who cites it
137 citing papers in PubMed, 192 citations in OpenAlex.
- The regulatory roles of non-coding RNAs in aerobic glycolysis and therapeutic potential in pancreatic ductal adenocarcinoma.Annals of medicine · 2026Review
- PINK1-mediated mitophagy supports lung cancer initiation and limits the efficacy ofScience advances · 2026Article
- Mitophagy-mediated immune evasion: Shared strategies of pathogens.Redox biology · 2026Review
- Unfolded Protein Response Pathways in Cancer: Mechanisms, Tumor Biology and Therapeutic Opportunities.Molecular diagnosis & therapy · 2026Review
- LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming.Cell death & disease · 2026Article
- Mitophagy interacts with mitochondrial dynamics and biogenesis, acting as a double-edged sword in digestive cancer.iScience · 2026Review
- Kaempferide in Alpinia officinarum Hance Exerts Anti-Hepatocellular Carcinoma Activity by Inhibiting Mitophagy Through Downregulation of BNIP3L.Journal of cellular and molecular medicine · 2026Article
- Molecular diversity of mitochondrial autophagy receptors: context-dependent effects in human health and disease.Cell death discovery · 2026Review
- Review
- Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities.Signal transduction and targeted therapy · 2026Review
- (+)-Miliusol suppresses the Warburg effect and induces regulated cell death in triple-negative breast cancer through targeting EIF3D and remodeling cancer metabolism.Acta pharmaceutica Sinica. B · 2026Article
- Time-Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Mitophagy and Ubiquitination Coordinate Context-Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dual Roles of NIX/BNIP3L in Tumors: Friend or Foe.Biology · 2026Review
- Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies.Cell death discovery · 2026Review
- Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects.Molecular cancer · 2026Review
- Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations.Signal transduction and targeted therapy · 2026Article
- Mitophagy in the pathogenesis and management of disease.Cell research · 2026Review
- Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity.Cancer research · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 8 institutions in 3 countries.
Timothy J Humpton *Cancer Research UK Beatson Institute, Glasgow, United Kingdom.ORCID 0000-0002-8030-9539
Brinda Alagesan *Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.ORCID 0000-0002-2984-5539
Gina M DeNicolaDepartment of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0001-6611-6696
Dan LuDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Georgi N YordanovCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Carl S LeonhardtCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Melissa A YaoCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Priya AlagesanCold Spring Harbor Laboratory, Cold Spring Harbor, New York.ORCID 0000-0002-2984-5539
Maya N ZaatariCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Youngkyu ParkCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Jeremy N SkepperCambridge Advanced Imaging Centre, Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Kay F MacleodThe Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois.
Pedro A Perez-ManceraDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom.
Michael P MurphyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-1115-9618
Gerard I EvanDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-0412-1216
Karen H VousdenThe Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-7365-1766
David A TuvesonCold Spring Harbor Laboratory, Cold Spring Harbor, New York. Dtuveson@cshl.edu.
Cold Spring Harbor Laboratory · USUniversity of Cambridge · GBCancer Research UK Scotland Institute · GBMay Institute · USMoffitt Cancer Center · USMRC Mitochondrial Biology Unit · GBThe Francis Crick Institute · GBUniversity of Liverpool · GB
Funding
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI Alea A. Mills · 1987 to 2026
$118.9MPancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9MUAB / UMN SPORE in Pancreatic CancerP50CA101955 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUCHSBAUM, DONALD J · 2010 to 2014
$11.1MCSHL-JAX Patient-Derived Models of Pancreatic Cancer as Systems for Investigating Tumor HeterogeneityU01CA224013 · NCI · COLD SPRING HARBOR LABORATORY · PI ROBSON, PAUL, TUVESON, DAVID A · 2018 to 2022
$4.2MFunctions of BNIP3 in lipid metabolism in the liver and in hepatocellular carcinomaR01CA200310 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD · 2016 to 2026
$3.6MNrf2 Regulation of Ductal Pancreatic Cancer Etiology and Treatment ResponseR01CA188134 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2017 to 2021
$3.0M(PQA-4) Organoid Omics To Detect And Defeat Ductal Pancreatic CancerR01CA190092 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2014 to 2017
$2.2MPreclinical Models for Cancer Therapeutic DevelopmentR50CA211506 · NCI · COLD SPRING HARBOR LABORATORY · PI PARK, YOUNGKYU · 2016 to 2025
$2.1MIntegrated Translational Cancer Science CenterU10CA180944 · NCI · COLD SPRING HARBOR LABORATORY · PI BAKER, LAURENCE HOWARD, LIU, EDISON TAK-BUN · 2014 to 2018
$2.0MAutophagy in Tumor Progression and MetastasisR01CA162405 · NCI · UNIVERSITY OF CHICAGO · PI MACLEOD, KAY F · 2012 to 2016
$1.6M(PQ5) Consequences of imbalanced mitophagy and mitochondrial biogenesis in cancerR01CA216242 · NCI · UNIVERSITY OF CHICAGO · PI MACLEOD, KAY F · 2017 to 2021
$1.6MTraining and Education ProgramP20CA192994 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI LI, ELLEN · 2015 to 2018
$1.6MCancer Research UK A12077Medical Research Council MC_UU_00015/3NCI NIH HHS F30 CA200240NCI NIH HHS P20 CA192994NCI NIH HHS P20 CA192996NCI NIH HHS P30 CA045508NCI NIH HHS P50 CA101955NCI NIH HHS R01 CA162405NCI NIH HHS R01 CA188134NCI NIH HHS R01 CA190092NCI NIH HHS R01 CA200310NCI NIH HHS R01 CA216242NCI NIH HHS R50 CA211506NCI NIH HHS U01 CA210240NCI NIH HHS U01 CA224013NCI NIH HHS U10 CA180944Wellcome TrustWellcome Trust 110159/Z/15/Z
Abstract
Activating
Indexed as
AnimalsCarcinoma, Pancreatic DuctalCell Line, TumorGene Expression Regulation, NeoplasticGlycolysisHumansMembrane ProteinsMiceMitochondriaMitophagyMutationNADPNeoplasm TransplantationOxidation-ReductionPancreatic NeoplasmsProto-Oncogene ProteinsBNIP3L protein, humanKRAS protein, humanMembrane ProteinsNADPProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Tumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.