Evidence map›Paper›PMID 31263018›Full record

ArticleMolecular pharmacology2019

Steady-State Activation and Modulation of the Concatemeric

Allison L Germann, Spencer R Pierce, Ariel B Burbridge, Joe Henry Steinbach, Gustav Akk

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. State-dependent energetics of GABABiophysical journal · 2024
    Article
  4. Article
  5. Article
  6. Modulation of the mammalian GABABritish journal of pharmacology · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Physiological role for GABANature communications · 2021
    Article
  12. Review
  13. Reduced Activation of the Synaptic-Type GABAMolecular pharmacology · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution.

Allison L GermannDepartment of Anesthesiology (A.L.G., S.R.P., A.B.B., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Spencer R PierceDepartment of Anesthesiology (A.L.G., S.R.P., A.B.B., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Ariel B BurbridgeDepartment of Anesthesiology (A.L.G., S.R.P., A.B.B., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Joe Henry SteinbachDepartment of Anesthesiology (A.L.G., S.R.P., A.B.B., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Gustav AkkDepartment of Anesthesiology (A.L.G., S.R.P., A.B.B., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu.
Taylor Family Institute for Innovative Psychiatric Research

Funding

SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
NIGMS NIH HHS R01 GM108580
6 · The paper itself

Abstract

The two-state coagonist model has been successfully used to analyze and predict peak current responses of the

Indexed as

Allosteric RegulationAnimalsbeta-AlanineGABA-A Receptor AgonistsMultiprotein ComplexesPentobarbitalPregnanolonePropofolReceptors, GABA-AXenopus laevisbeta-AlanineGABA-A Receptor AgonistsMultiprotein ComplexesPentobarbitalPregnanolonePropofolReceptors, GABA-A

Identifiers

PMID31263018
PMCPMC6658920
OpenAlexW2953856740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.