Evidence map›Paper›PMID 31262999›Full record

ArticleMolecular and cellular biology2019

CCN1-Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis.

Sangmi Lee, Afruja Ahad, Michele Luu, Sohyun Moon, JoyAnn Caesar, Wellington V Cardoso, Maria B Grant, Brahim Chaqour

Abstract read
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  8. Article
  9. CCN proteins: opportunities for clinical studies-a personal perspective.Journal of cell communication and signaling · 2023
    Review
  10. Review
  11. KnockdownBiomedicines · 2023
    Article
  12. Article
  13. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sangmi LeeDepartment of Cell Biology, Downstate Medical Center, Brooklyn, New York, USA.
Afruja AhadDepartment of Cell Biology, Downstate Medical Center, Brooklyn, New York, USA.
Michele LuuDepartment of Cell Biology, Downstate Medical Center, Brooklyn, New York, USA.
Sohyun MoonDepartment of Cell Biology, Downstate Medical Center, Brooklyn, New York, USA.
JoyAnn CaesarDepartment of Cell Biology, Downstate Medical Center, Brooklyn, New York, USA.
Wellington V CardosoColumbia Center for Human Development and Pulmonary Allergy Critical Care, Department of Medicine, Columbia University Medical Center, New York, New York, USA.
Maria B GrantDepartment of Ophthalmology, University of Alabama, Birmingham, Alabama, USA.
Brahim ChaqourDepartment of Cell Biology, Downstate Medical Center, Brooklyn, New York, USA bchaqour@downstate.edu.ORCID 0000-0002-8516-4324
SUNY Downstate Health Sciences University · USColumbia University Irving Medical Center · USUniversity of Alabama at Birmingham · US

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
Regulation and Function of the Matricellular Protein CCN1 in Ischemic RetinopathyR01EY022091 · NEI · SUNY DOWNSTATE MEDICAL CENTER · PI CHAQOUR, BRAHIM · 2012 to 2017
$2.0M
CTGF Function in Retinal Vessel Development and PathologyR01EY024998 · NEI · SUNY DOWNSTATE MEDICAL CENTER · PI DANIAS, JOHN · 2017 to 2020
$1.6M
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY022091NEI NIH HHS R01 EY024998
6 · The paper itself

Abstract

Cellular communication network factor 1 (CCN1) is a dynamically expressed, matricellular protein required for vascular development and tissue repair. The

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell LineCell ProliferationCysteine-Rich Protein 61Disease Models, AnimalEndothelial CellsFeedback, PhysiologicalFemaleGene Expression RegulationHumansMaleMicePromoter Regions, GeneticRetinal DiseasesRetinal VesselsAdaptor Proteins, Signal TransducingCCN1 protein, humanCysteine-Rich Protein 61Transcription FactorsYAP1 protein, humanYAP-Signaling ProteinsangiogenesisCCN1extracellular matrixischemic retinopathyYAP

Identifiers

PMID31262999
PMCPMC6712939
OpenAlexW2954252477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.