Evidence map›Paper›PMID 31262980›Full record

ArticleInfection and immunity2019

Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii.

Chad R Marion, Jaewook Lee, Lokesh Sharma, Kyong-Su Park, Changjin Lee, Wei Liu, Pei Liu, Jingjing Feng, Yong Song Gho, Charles S Dela Cruz

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Outer Membrane Vesicles FromJournal of extracellular biology · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Virulence Factors and Pathogenicity Mechanisms ofAntibiotics (Basel, Switzerland) · 2023
    Review
  16. Bacterial Membrane Vesicles: Physiological Roles, Infection Immunology, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Chad R Marion *Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jaewook Lee *Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
Lokesh SharmaSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Kyong-Su ParkDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
Changjin LeeDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
Wei LiuSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Pei LiuSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Jingjing FengSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Yong Song GhoDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea ysgho@postech.ac.kr charles.delacruz@yale.edu.
Charles S Dela CruzSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA ysgho@postech.ac.kr charles.delacruz@yale.edu.
Yale University · USPohang University of Science and Technology · KR

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Pneumonia due to Gram-negative bacteria is associated with high mortality.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnimalsBacterial Outer Membrane ProteinsChemokinesCytokinesDisease Models, AnimalMicePneumoniaSecretory VesiclesToll-Like Receptor 2Toll-Like Receptor 4Bacterial Outer Membrane ProteinsChemokinesCytokinesToll-Like Receptor 2Toll-Like Receptor 4Acinetobacterexosomeslung inflammationTLR

Identifiers

PMID31262980
PMCPMC6704609
OpenAlexW2955676332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.