Evidence map›Paper›PMID 31262948›Full record

ReviewCold Spring Harbor perspectives in biology2019

Relating Structure and Dynamics in RNA Biology.

Kevin P Larsen, Junhong Choi, Arjun Prabhakar, Elisabetta Viani Puglisi, Joseph D Puglisi

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. NMR Chemical Exchange Measurements Reveal ThatJournal of the American Chemical Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kevin P Larsen *Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305.
Junhong Choi *Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305.
Arjun PrabhakarDepartment of Structural Biology, Stanford University School of Medicine, Stanford, California 94305.
Elisabetta Viani PuglisiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, California 94305.
Joseph D PuglisiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, California 94305.

Funding

X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9M
STRUCTURAL BASIS FOR RIBOSOME FUNCTIONSR01GM051266 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI PUGLISI, JOSEPH D · 1995 to 2021
$7.7M
Molecular Biophysics Training Program at StanfordT32GM008294 · NIGMS · STANFORD UNIVERSITY · PI HUANG, KERWYN C. · 1989 to 2019
$7.4M
Structure and Function of the Hepatitis C Virus GenomeR37AI047365 · NIAID · STANFORD UNIVERSITY · PI SARNOW, PETER · 2011 to 2019
$4.0M
THE PROKARYOTIC-LIKE IRES IN HCV AS A DRUG TARGETR01AI047365 · NIAID · STANFORD UNIVERSITY · PI PUGLISI, JOSEPH D, SARNOW, PETER · 1999 to 2010
$3.8M
Dynamics of eukaryotic translation initiation and its controlR01GM113078 · NIGMS · STANFORD UNIVERSITY · PI PUGLISI, JOSEPH D · 2016 to 2021
$2.9M
Modulation of internal ribosome entry by ribosomal protein RPS25R01AI099506 · NIAID · STANFORD UNIVERSITY · PI PUGLISI, JOSEPH D, SARNOW, PETER · 2014 to 2018
$2.9M
NIAID NIH HHS P50 AI150464NIAID NIH HHS R01 AI047365NIAID NIH HHS R01 AI099506NIAID NIH HHS R37 AI047365NIGMS NIH HHS P50 GM082545NIGMS NIH HHS R01 GM051266NIGMS NIH HHS R01 GM113078NIGMS NIH HHS T32 GM008294
6 · The paper itself

Abstract

Recent advances in structural biology methods have enabled a surge in the number of RNA and RNA-protein assembly structures available at atomic or near-atomic resolution. These complexes are often trapped in discrete conformational states that exist along a mechanistic pathway. Single-molecule fluorescence methods provide temporal resolution to elucidate the dynamic mechanisms of processes involving complex RNA and RNA-protein assemblies, but interpretation of such data often requires previous structural knowledge. Here we highlight how single-molecule tools can directly complement structural approaches for two processes--translation and reverse transcription-to provide a dynamic view of molecular function.

Indexed as

Nucleic Acid ConformationRNASingle Molecule ImagingRNA

Identifiers

PMID31262948
PMCPMC6601459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.