Evidence map›Paper›PMID 31262826›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Pandemic fluoroquinolone resistant

Veronika Tchesnokova, Matthew Radey, Sujay Chattopadhyay, Lydia Larson, Jamie Lee Weaver, Dagmara Kisiela, Evgeni V Sokurenko

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
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  12. Unraveling the Resistome, Virulome, and Pathogenicity ofInternational journal of microbiology · 2025
    Article
  13. The fitness connection of antibiotic resistance.Frontiers in microbiology · 2025
    Article
  14. Review
  15. Gut residentmedRxiv : the preprint server for health sciences · 2024
    Article
  16. Article
  17. Antimicrobial agents and chemotherapy · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Veronika TchesnokovaDepartment of Microbiology, University of Washington, Seattle, WA 98105.
Matthew RadeyDepartment of Microbiology, University of Washington, Seattle, WA 98105.
Sujay ChattopadhyayInstitute of Advanced Studies and Research, JIS University, Kolkata 700091, India.
Lydia LarsonDepartment of Microbiology, University of Washington, Seattle, WA 98105.
Jamie Lee WeaverDepartment of Microbiology, University of Washington, Seattle, WA 98105.
Dagmara KisielaDepartment of Microbiology, University of Washington, Seattle, WA 98105.
Evgeni V SokurenkoDepartment of Microbiology, University of Washington, Seattle, WA 98105; evs@uw.edu.ORCID 0000-0003-2806-4121
University of Washington · US

Funding

Molecular Clonality of Uropathogenic E. ColiR01AI106007 · NIAID · UNIVERSITY OF WASHINGTON · PI SOKURENKO, EVGENI VENIAMINOVIC · 2014 to 2024
$7.5M
Clonotyping Technology for Prediction of Antibiotic ResistanceR42AI116114 · NIAID · IDGENOMICS, INC. · PI SOKURENKO, EVGENI VENIAMINOVIC, ZUCKERMAN, LINDA · 2016 to 2018
$3.0M
Clonotyping Technology for Prediction of Antibiotic ResistanceR41AI116114 · NIAID · IDGENOMICS, INC. · PI APRIKIAN, PAVEL, SOKURENKO, EVGENI VENIAMINOVIC · 2015 to 2015
$214k
NIAID NIH HHS R01 AI106007NIAID NIH HHS R41 AI116114NIAID NIH HHS R42 AI116114
6 · The paper itself

Abstract

Global growth in antibiotic resistance is a major social problem. A high level of resistance to fluoroquinolones requires the concurrent presence of at least 3 mutations in the target proteins-2 in DNA gyrase (GyrA) and 1 in topoisomerase IV (ParC), which occur in a stepwise manner. In the

Indexed as

Genetic LociHomologous RecombinationChromosomes, BacterialDNA GyraseDNA Topoisomerase IVDrug Resistance, Multiple, BacterialEscherichia coli ProteinsFluoroquinolonesGene Transfer, HorizontalHumansMicrobial Sensitivity TestsMutationPandemicsUrinary Tract InfectionsUropathogenic Escherichia coliDNA GyraseDNA Topoisomerase IVEscherichia coli ProteinsFluoroquinolonesEscherichia coli ST1193homologous recombinationQRDR mutationsresistance to fluoroquinolonesurinary tract infections

Identifiers

PMID31262826
PMCPMC6642405
OpenAlexW2955217214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.