Evidence map›Paper›PMID 31262819›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.

Kohei Fujita, Svetoslav Chakarov, Tetsuro Kobayashi, Keiko Sakamoto, Benjamin Voisin, Kaibo Duan, Taneaki Nakagawa, Keisuke Horiuchi, Masayuki Amagai, Florent Ginhoux and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. CD4Oncoimmunology · 2026
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  8. Review
  9. Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Article
  11. TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Kohei FujitaDepartment of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Svetoslav ChakarovSingapore Immunology Network, Agency for Science, Technology and Research, Biopolis, 138648 Singapore.
Tetsuro KobayashiDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Keiko SakamotoDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Benjamin VoisinDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Kaibo DuanSingapore Immunology Network, Agency for Science, Technology and Research, Biopolis, 138648 Singapore.
Taneaki NakagawaDepartment of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Keisuke HoriuchiDepartment of Orthopedic Surgery, National Defense Medical College, Tokorozawa 359-8513, Japan.
Masayuki AmagaiDepartment of Dermatology, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID 0000-0003-3314-7052
Florent GinhouxSingapore Immunology Network, Agency for Science, Technology and Research, Biopolis, 138648 Singapore.
Keisuke NagaoDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; keisuke.nagao@nih.gov.ORCID 0000-0002-7005-3138
National Institutes of Health · USAgency for Science, Technology and Research · SGKeio University · JPNational Defense Medical College · JP

Funding

Exploring mechanisms that govern immune homeostasis in skinZIABC011561 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NAGAO, KEISUKE · 2014 to 2021
$10.1M
6 · The paper itself

Abstract

Conventional dendritic cells (cDCs) derive from bone marrow (BM) precursors that undergo cascades of developmental programs to terminally differentiate in peripheral tissues. Pre-cDC1s and pre-cDC2s commit in the BM to each differentiate into CD8α

Indexed as

ADAM10 ProteinAmyloid Precursor Protein SecretasesAnimalsBone Marrow TransplantationCell-Derived MicroparticlesCell DifferentiationCell MembraneDendritic CellsDNA-Binding ProteinsFemaleFibroblastsHematopoietic Stem CellsImmunity, CellularMaleMembrane ProteinsMiceADAM10 ProteinAdam10 protein, mouseAmyloid Precursor Protein SecretasesDNA-Binding Proteinsflt3 ligand proteinMembrane ProteinsRag2 protein, mouseRecombinant ProteinsADAM10dendritic cellsimmunology

Identifiers

PMID31262819
PMCPMC6642353
OpenAlexW2953610917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.