Evidence map›Paper›PMID 31262817›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

Chenfeng Wang, Yang Yang, Guang Zhang, Jingxin Li, Xianning Wu, Xiaoling Ma, Ge Shan, Yide Mei

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 94 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chenfeng WangDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Yang YangDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Guang ZhangDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Jingxin LiDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Xianning WuDepartment of Thoracic Surgery, First Affiliated Hospital of USTC, USTC, 230027 Hefei, Anhui, China.
Xiaoling MaDepartment of Laboratory Medicine, First Affiliated Hospital of USTC, USTC, 230027 Hefei, Anhui, China.
Ge ShanDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China.
Yide MeiDivision of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China; meiyide@ustc.edu.cn.
University of Science and Technology of China · CNChinese Academy of Sciences · CNHefei Institutes of Physical Science · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deregulated expression of c-Myc is an important molecular hallmark of cancer. The oncogenic function of c-Myc has been largely attributed to its intrinsic nature as a master transcription factor. Here, we report the long noncoding RNA (lncRNA) E2F1 messenger RNA (mRNA) stabilizing factor (EMS) as a direct c-Myc transcriptional target. EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression. Mechanistically, EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression. Furthermore, EMS is able to connect c-Myc to cell cycle control and tumorigenesis via modulating E2F1 mRNA stability. Together, these findings reveal a previously unappreciated mechanism through which c-Myc induces E2F1 expression and also implicate EMS as an important player in the regulation of c-Myc function.

Indexed as

A549 CellsAnimalsCarcinogenesisE2F1 Transcription FactorG1 Phase Cell Cycle CheckpointsGene Expression Regulation, NeoplasticGene Knockdown TechniquesHEK293 CellsHeterogeneous-Nuclear Ribonucleoprotein Group CHumansMiceNeoplasmsProto-Oncogene Proteins c-mycRNA, Long NoncodingRNA, MessengerRNA, Small InterferingE2F1 protein, humanE2F1 Transcription FactorHeterogeneous-Nuclear Ribonucleoprotein Group CMYC protein, humanProto-Oncogene Proteins c-mycRALY protein, humanRNA, Long NoncodingRNA, MessengerRNA, Small Interferingc-MycE2F1lncRNAtumorigenesis

Identifiers

PMID31262817
PMCPMC6642410
OpenAlexW2953472442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.