Evidence map›Paper›PMID 31262815›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.

Jonathan Zirin, Xiaochun Ni, Laura M Sack, Donghui Yang-Zhou, Yanhui Hu, Roderick Brathwaite, Martha L Bulyk, Stephen J Elledge, Norbert Perrimon

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Aminoacyl-tRNA synthetases.RNA (New York, N.Y.) · 2020
    Review
  8. Review
  9. Review
  10. The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jonathan ZirinDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Xiaochun NiDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Laura M SackDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Donghui Yang-ZhouDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Yanhui HuDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Roderick BrathwaiteDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Martha L BulykDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Stephen J ElledgeDepartment of Genetics, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-7923-6283
Norbert PerrimonDepartment of Genetics, Harvard Medical School, Boston, MA 02115; perrimon@genetics.med.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USHoward Hughes Medical Institute · US

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Characterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2M
Howard Hughes Medical InstituteNCI NIH HHS P01 CA120964NIAMS NIH HHS R01 AR057352NIGMS NIH HHS R01 GM084947
6 · The paper itself

Abstract

Aberrant MYC oncogene activation is one of the most prevalent characteristics of cancer. By overlapping datasets of

Indexed as

Amino Acyl-tRNA SynthetasesAnimalsAnimals, Genetically ModifiedCell LineCell SurvivalDNA-Binding ProteinsDrosophila ProteinsEpithelial CellsFemaleGene Expression Regulation, NeoplasticHumansInsulinMaleNeoplasmsRNA InterferenceSignal TransductionAmino Acyl-tRNA SynthetasesDNA-Binding ProteinsDrosophila ProteinsInsulinMyc protein, DrosophilaTranscription FactorscancerDrosophilaMYCnucleolustRNA synthetase

Identifiers

PMID31262815
PMCPMC6642371
OpenAlexW2955408701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.