ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Increased Thalamocortical Connectivity in Schizophrenia Correlates With Sleep Spindle Deficits: Evidence for a Common Pathophysiology.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 82 citations in OpenAlex.
- The effects of eszopiclone on sleep spindles and memory consolidation in schizophrenia: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Slow Oscillation-Sleep Spindle Coupling Is Associated With Expectancy Measures of Fear Extinction Retention in Trauma-Exposed Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Sleep Spindle Measures in Japanese Patients With Drug-Naïve Schizophrenia Using Standard Polysomnography Data: A Retrospective Pilot Study.Early intervention in psychiatry · 2026Article
- Hyperactivation of distinct thalamic nuclei differentially impairs sleep physiology in rats.Molecular psychiatry · 2026Article
- The association between sleep spindles and cognitive performance in euthymic bipolar disorder.Translational psychiatry · 2026Article
- The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.Molecular neurobiology · 2026Review
- Sleep and wake markers of thalamocortical functioning in early-course psychosis and first-degree relatives.Schizophrenia (Heidelberg, Germany) · 2026Article
- Distance- and hierarchy-dependent functional dysconnectivity in schizophrenia and its association with cortical microstructure.NeuroImage. Clinical · 2026Article
- Sleep Spindle Abnormalities as Neurophysiological Biomarkers of Schizophrenia Spectrum Disorders: From Cellular Mechanisms and Neural Circuits to Clinical Implications.Biological psychiatry · 2025Review
- Sleep and Mental Health: Unveiling the Critical Role of Sleep in Brain Function and Psychiatric Disorders.Biological psychiatry · 2025Article
- NREM Sleep Oscillations Are Associated With Anxiety and Negative Affect in Young Adults.Journal of sleep research · 2025Article
- Review
- Multimodal evidence of mediodorsal thalamus-prefrontal circuit dysfunctions in clinical high-risk for psychosis: findings from a combined 7T fMRI, MRSI and sleep Hd-EEG study.Molecular psychiatry · 2025Article
- Age-Related Changes in Sleep and Its Implications for Cognitive Decline in Aging Persons With Schizophrenia: A Critical Review.Schizophrenia bulletin · 2025Review
- Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.Schizophrenia (Heidelberg, Germany) · 2025Article
- Slow oscillation-sleep spindle coupling is associated with fear extinction retention in trauma-exposed individuals.bioRxiv : the preprint server for biology · 2025Article
- Sleep and psychiatric disorders: Bidirectional interactions and shared neurobiological mechanisms.PLOS mental health · 2025Review
- Study Protocol: Global Research Initiative on the Neurophysiology of Schizophrenia (GRINS) project.BMC psychiatry · 2024Article
- Optogenetic inhibition of the limbic corticothalamic circuit does not alter spontaneous oscillatory activity, auditory-evoked oscillations, and deviant detection.Scientific reports · 2024Article
- Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders.Cell stem cell · 2024Article
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8 authors at 3 institutions in 1 country.
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Abstract
backgroundConverging evidence implicates abnormal thalamocortical interactions in the pathophysiology of schizophrenia. This evidence includes consistent findings of increased resting-state functional connectivity of the thalamus with somatosensory and motor cortex during wake and reduced spindle activity during sleep. We hypothesized that these abnormalities would be correlated, reflecting a common mechanism: reduced inhibition of thalamocortical neurons by the thalamic reticular nucleus (TRN). The TRN is the major inhibitory nucleus of the thalamus and is abnormal in schizophrenia. Reduced TRN inhibition would be expected to lead to increased and less filtered thalamic relay of sensory and motor information to the cortex during wake and reduced burst firing necessary for spindle initiation during sleep.
methodsOvernight polysomnography and resting-state functional connectivity magnetic resonance imaging were performed in 26 outpatients with schizophrenia and 30 demographically matched healthy individuals. We examined the relations of sleep spindle density during stage 2 non-rapid eye movement sleep with connectivity of the thalamus to the cortex during wakeful rest.
resultsAs in prior studies, patients with schizophrenia exhibited increased functional connectivity of the thalamus with bilateral somatosensory and motor cortex and reduced sleep spindle density. Spindle density inversely correlated with thalamocortical connectivity, including in somotosensory and motor cortex, regardless of diagnosis.
conclusionsThese findings link two biomarkers of schizophrenia-the sleep spindle density deficit and abnormally increased thalamocortical functional connectivity-and point to deficient TRN inhibition as a plausible mechanism. If TRN-mediated thalamocortical dysfunction increases risk for schizophrenia and contributes to its manifestations, understanding its mechanism could guide the development of targeted interventions.
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