Evidence map›Paper›PMID 31262215›Full record

ArticleEpigenetics2019

Global modulation in DNA epigenetics during pro-inflammatory macrophage activation.

Nikhil Jain, Tamar Shahal, Tslil Gabrieli, Noa Gilat, Dmitry Torchinsky, Yael Michaeli, Viola Vogel, Yuval Ebenstein

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Metabolic Endotoxemia: From the Gut to Neurodegeneration.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Lentinan and β-glucan extract from shiitake mushroom,Iranian journal of basic medical sciences · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. DNA Labeling Using DNA Methyltransferases.Advances in experimental medicine and biology · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nikhil JainDepartment of Health Sciences and Technology, Laboratory of Applied Mechanobiology, Institute of Translational Medicine, ETH Zurich , Zurich , Switzerland.ORCID 0000-0001-8963-9254
Tamar ShahalSagol Center for the Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel.
Tslil GabrieliRaymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University , Tel Aviv , Israel.
Noa GilatRaymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University , Tel Aviv , Israel.
Dmitry TorchinskyRaymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University , Tel Aviv , Israel.
Yael MichaeliRaymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University , Tel Aviv , Israel.
Viola VogelDepartment of Health Sciences and Technology, Laboratory of Applied Mechanobiology, Institute of Translational Medicine, ETH Zurich , Zurich , Switzerland.ORCID 0000-0003-2898-7671
Yuval EbensteinRaymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University , Tel Aviv , Israel.ORCID 0000-0002-7107-7529
Tel Aviv University · ILETH Zurich · CH

Funding

European Research Council 337830
6 · The paper itself

Abstract

DNA methylation patterns create distinct gene-expression profiles. These patterns are maintained after cell division, thus enabling the differentiation and maintenance of multiple cell types from the same genome sequence. The advantage of this mechanism for transcriptional control is that chemical-encoding allows to rapidly establish new epigenetic patterns '

Indexed as

DNA MethylationEpigenesis, GeneticAnimalsCells, CulturedCpG IslandsMacrophage ActivationMacrophagesMiceDNA methylationMacrophage activationmass spectroscopyRNA sequencingsingle-molecule imaging

Identifiers

PMID31262215
PMCPMC6791700
OpenAlexW2954850188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.