Evidence map›Paper›PMID 31262060›Full record

ArticleCells2019

Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury.

Kuo-How Huang, Siao-Syun Guan, Wei-Han Lin, Cheng-Tien Wu, Meei-Ling Sheu, Chih-Kang Chiang, Shing-Hwa Liu

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Kuo-How HuangDepartment of Urology, College of Medicine and Hospital, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-0989-0578
Siao-Syun GuanInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan 325, Taiwan.
Wei-Han LinInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Cheng-Tien WuDivision of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
Meei-Ling SheuInstitute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan.
Chih-Kang ChiangInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Shing-Hwa LiuInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan. shinghwaliu@ntu.edu.tw.ORCID 0000-0002-9976-1197
National Taiwan University · TWAtomic Energy Council · TWNational Chung Hsing University · TWNational Taiwan University Hospital · TWTaipei Medical University-Shuang Ho Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy still remains unclear. Here, calbindin-D28k protein expression was unexpectedly induced in the renal tubules of

Indexed as

AnimalsCalbindin 1Diabetes Mellitus, Type 2Diabetic NephropathiesDisease Models, AnimalEndoplasmic ReticulumEndoplasmic Reticulum StressFibrosisGene Knockdown TechniquesGlycation End Products, AdvancedHumansKidney Tubules, DistalMaleMesangial CellsMicePhenylbutyrates4-phenylbutyric acidAGER protein, humanCALB1 protein, humanCalb1 protein, mouseCalbindin 1Glycation End Products, AdvancedPhenylbutyratesReceptor for Advanced Glycation End ProductsRNA, Small Interferingadvanced glycation end productscalbindin-D28kdiabetic nephropathyrenal fibrosisrenal proximal tubule

Identifiers

PMID31262060
PMCPMC6678974
OpenAlexW2954179537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.