ArticleNutrients2019
Suppression of Food Allergic Symptoms by Raw Cow's Milk in Mice is Retained after Skimming but Abolished after Heating the Milk-A Promising Contribution of Alkaline Phosphatase.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Harnessing the Farm Effect: Microbial Products for the Treatment and Prevention of Asthma Throughout Life.Immunological reviews · 2025Review
- Environmental Exposures may Hold the Key; Impact of Air Pollution, Greenness, and Rural/Farm Lifestyle on Allergic Outcomes.Current allergy and asthma reports · 2023Review
- Protective Effect of Alkaline Phosphatase Supplementation on Infant Health.Foods (Basel, Switzerland) · 2022Review
- Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.Frontiers in nutrition · 2022Review
- Iron-Deficiency in Atopic Diseases: Innate Immune Priming by Allergens and Siderophores.Frontiers in allergy · 2022Review
- Effect of Food Endotoxin on Infant Health.Toxins · 2021Review
- Raw Milk-Induced Protection against Food Allergic Symptoms in Mice Is Accompanied by Shifts in Microbial Community Structure.International journal of molecular sciences · 2021Article
- Perinatal and Early-Life Nutrition, Epigenetics, and Allergy.Nutrients · 2021Review
- The Hygiene Hypothesis and New Perspectives-Current Challenges Meeting an Old Postulate.Frontiers in immunology · 2021Review
- Antibiotic Intervention Affects Maternal Immunity During Gestation in Mice.Frontiers in immunology · 2021Article
- Raw Cow Milk Consumption and the Atopic March.Frontiers in pediatrics · 2021Article
- Importance of food in the control of inflammation in atopic dermatitis.Experimental and therapeutic medicine · 2020Article
- Direct Inhibition of the Allergic Effector Response by Raw Cow's Milk-An Extensive In Vitro Assessment.Cells · 2020Article
- Raw milk producers with high levels of hygiene and safety.Epidemiology and infection · 2020Article
- The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma.Frontiers in immunology · 2020Review
- The Two Faces of Cow's Milk and Allergy: Induction of Cow's Milk Allergy vs. Prevention of Asthma.Nutrients · 2019Article
- Raw Cow's Milk Reduces Allergic Symptoms in a Murine Model for Food Allergy-A Potential Role For Epigenetic Modifications.Nutrients · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Raw cow's milk was previously shown to suppress allergic symptoms in a murine model for food allergy. In the present study, we investigated the contribution of fat content and heat-sensitive milk components to this allergy-protective effect. In addition, we determined the potency of alkaline phosphatase (ALP), a heat-sensitive raw milk component, to affect the allergic response. C3H/HeOuJ mice were treated with raw milk, pasteurized milk, skimmed raw milk, pasteurized milk spiked with ALP, or phosphate-buffered saline for eight days prior to sensitization and challenge with ovalbumin (OVA). Effects of these milk types on the allergic response were subsequently assessed. Similar to raw milk, skimmed raw milk suppressed food allergic symptoms, demonstrated by a reduced acute allergic skin response and low levels of OVA-specific IgE and Th2-related cytokines. This protective effect was accompanied by an induction of CD103
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.