ReviewBioengineering (Basel, Switzerland)2019
Sources of Collagen for Biomaterials in Skin Wound Healing.
Review in Bioengineering (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review.Frontiers in medicine · 2023Pooled it
- PVA/chitosan-based hydrogels integrated with tilapia skin-derived collagen and Urtica dioica offers a promising approach for effective burn wound healing via transcriptional modulation of bFgf, Mmp2, Jak/Stat3, and α-Sma signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Skin symptoms and their impact on quality-of-life in adults with osteogenesis imperfecta.Journal of the Endocrine Society · 2026Article
- Injectable Hydroxyapatite-Reinforced Methacrylated Recombinant Type III Collagen Microgels for Soft-Tissue Filling.Gels (Basel, Switzerland) · 2026Article
- Macrophage regulation of extracellular matrix remodeling in aging skeletal muscle.Ageing research reviews · 2026Review
- Article
- Promising Natural Polymer-Based Dressings for Diabetic Foot Ulcers: Mechanisms, Preclinical Studies, and Clinical Applications.Pharmaceutics · 2026Review
- Biocidal Elastic Films Based on Cod Collagen, Pectin, and PMMA Copolymers: Effectiveness in Healing Burn Surfaces in Small Animals.Polymers · 2026Article
- Hypoxia-preconditioned gingiva-derived mesenchymal stem cell-conditioned medium accelerates burn wound healing.Scientific reports · 2026Article
- Characterization of cutaneous wound healing in swine.JID innovations : skin science from molecules to population health · 2026Article
- Comparative Late Effects of Hemostatic Biomaterials on Wound Healing at 14 and 30 Days: An In Vivo Animal Study.Journal of functional biomaterials · 2026Article
- Fabrication and Characterization of Fish Tropocollagen Sponge Enriched with Nanodiamonds for Potential Wound Dressing Applications.Materials (Basel, Switzerland) · 2026Article
- Preparation of Uniform PEG-PLLA Microspheres via Membrane Emulsification for Soft Tissue Filling Applications.Journal of functional biomaterials · 2026Article
- An engineered and scalable human cell-derived extracellular matrix demonstrates advantages over recombinant collagen in biomimicry and wound healing.Frontiers in bioengineering and biotechnology · 2026Article
- Recombinant humanized type VII collagen for skin repair and regeneration: prospects for reconstructing the dermal-epidermal junction.Frontiers in medicine · 2026Review
- Collagen from Marine Sources for Potential Application in Wound Treatment.Progress in molecular and subcellular biology · 2026Review
- Bioinspired electrospun janus nanofibrous dressing for synergistic antibacterial activity and tissue regeneration.Frontiers in microbiology · 2026Article
- Versatility of Collagen as a Natural Biopolymer for Biomedical, Food, and Cosmetic Applications.Current protein & peptide science · 2026Review
- Evaluation of the safety and functional effects of recombinant humanized type III collagen in food toxicology.Frontiers in medicine · 2026Article
- Unveiling the Potential of Fish Swim Bladder-Derived Biomaterials in Urological Care.Advances in urology · 2026Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Collagen is the most frequently used protein in the fields of biomaterials and regenerative medicine. Within the skin, collagen type I and III are the most abundant, while collagen type VII is associated with pathologies of the dermal-epidermal junction. The focus of this review is mainly collagens I and III, with a brief overview of collagen VII. Currently, the majority of collagen is extracted from animal sources; however, animal-derived collagen has a number of shortcomings, including immunogenicity, batch-to-batch variation, and pathogenic contamination. Recombinant collagen is a potential solution to the aforementioned issues, although production of correctly post-translationally modified recombinant human collagen has not yet been performed at industrial scale. This review provides an overview of current collagen sources, associated shortcomings, and potential resolutions. Recombinant expression systems are discussed, as well as the issues associated with each method of expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.