Evidence map›Paper›PMID 31261965›Full record

ReviewNutrients2019

Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy.

Birgit Linhart, Raphaela Freidl, Olga Elisyutina, Musa Khaitov, Alexander Karaulov, Rudolf Valenta

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 57 citations in OpenAlex.

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  19. Microarray-Based Allergy Diagnosis: Quo Vadis?Frontiers in immunology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Birgit LinhartDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria. birgit.linhart@meduniwien.ac.at.
Raphaela FreidlDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria.
Olga ElisyutinaNRC Institute of Immunology FMBA of Russia, 115478, Moscow, Russia.
Musa KhaitovNRC Institute of Immunology FMBA of Russia, 115478, Moscow, Russia.
Alexander KaraulovLaboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Rudolf ValentaDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria.
Institute of Immunology and Physiology · RUMedical University of Vienna · ATSechenov University · RU

Funding

Austrian Science Fund F4605Austrian Science Fund FWF F 4605
6 · The paper itself

Abstract

Cow´s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow´s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow´s milk allergens. Here, we provide an overview about the allergen molecules in cow´s milk and the advantages of the molecular diagnosis of IgE sensitization to cow´s milk by serology. In addition, we review current strategies for prevention and treatment of cow´s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.

Indexed as

AllergensMolecular Diagnostic TechniquesBiomarkersHumansImmunoglobulin EMilk HypersensitivityMilk ProteinsPhenotypePredictive Value of TestsTreatment OutcomeAllergensBiomarkersImmunoglobulin EMilk Proteinscow’s milk allergensCow’s milk allergydiagnosis of cow’s milk allergymolecular diagnosisprevention of cow’s milk allergytreatment of cow’s milk allergy

Identifiers

PMID31261965
PMCPMC6683018
OpenAlexW2954101355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.