ArticleBiomedicines2019
Zimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis.
Article in Biomedicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Occlusal Force Changes in Growing Patients Treated with the Three Bite Plane Appliance: A Prospective Study.Dentistry journal · 2026Article
- Mandibular Arch Morphology in Normodivergent Patients With Impacted Maxillary Canines: A Case-Control Study.International journal of dentistry · 2026Article
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
- Bone Regeneration and Polyetheretherketone Implants in Maxillo-Facial Surgery and Neurosurgery: A Multidisciplinary Study.Biology · 2024Article
- Analysis of ultra-short implants with different angulations: a retrospective case-control study with 2 to 9 years of follow-up.Clinical oral investigations · 2024Article
- Zimmermann-Laband syndrome and infantile systemic hyalinosis: an enigma with two separate terms with overlapping features: a case report.BMC pediatrics · 2023Article
- A novel geneeLife · 2022Article
- Oral Microbiome, Oral Health and Systemic Health: A Multidirectional Link.Biomedicines · 2022Article
- Seven-year follow-up of a patient with hereditary gingival fibromatosis treated with a multidisciplinary approach: case report.BMC oral health · 2021Article
- Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3-a subgroup of KEuropean journal of human genetics : EJHG · 2021Article
- Oral Conditions and Oral Health-Related Quality of Life of People with Ehlers-Danlos Syndromes (EDS): A Questionnaire-Based Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2020Article
- Zimmermann-Laband syndrome-associated hereditary gingival fibromatosis.Journal of Indian Society of PeriodontologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundZimmermann-Laband-1 syndrome (ZLS-1; OMIM# 135500) is a rare genetic disorder whose oral pathognomonic sign is the development of progressive, diffuse, and severe gingival hypertrophy. Most children with abnormally gingival hyperplasia may also present multiple unerupted teeth and skeletal deformities of maxillary arches (i.e., skeletal anterior open bite). Despite phenotypic variability of the clinical spectrum, gingival fibromatosis is the hallmark of ZLS-1.
methodIn this study, we report a 3-year-old male patient with a ZLS-1-related gingival overgrowth and failure of eruption of the deciduous teeth in the molar area. Surgical excision was performed under general anesthesia.
resultsAt three weeks follow-up, esthetics was significantly improved in terms of gingival appearance, and teeth eruption allowed an adequate masticatory function.
conclusionIn severe cases, surgical removal of the hyperplasic fibrous tissue may be required to expose unerupted teeth and establish a proper gingival contour. Surgical excision under general anesthesia is an elective procedure for patients with special needs, mental disability, as well as young and adult patients with dental anxiety type II and IV associated with poor oral health.
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