Evidence map›Paper›PMID 31261930›Full record

Trial reportNutrients2019

Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration.

Jed W Fahey, Kristina L Wade, Katherine K Stephenson, Anita A Panjwani, Hua Liu, Grace Cornblatt, Brian S Cornblatt, Stacy L Ownby, Edward Fuchs, Walter David Holtzclaw and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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  19. The Anti-AGEing and RAGEing Potential of Isothiocyanates.Molecules (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jed W FaheyCullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA. jfahey@jhmi.edu.ORCID 0000-0002-2129-1834
Kristina L WadeCullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.
Katherine K StephensonCullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.
Anita A PanjwaniCullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-7833-7162
Hua LiuCullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-9141-5268
Grace CornblattNutramax Laboratories Consumer Care, Inc., Edgewood, MD 21040, USA.
Brian S CornblattNutramax Laboratories Consumer Care, Inc., Edgewood, MD 21040, USA.
Stacy L OwnbyNutramax Laboratories Consumer Care, Inc., Edgewood, MD 21040, USA.
Edward FuchsDivision of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Walter David HoltzclawCullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.
Lawrence J CheskinDepartment of Health Behavior and Society, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205 USA.ORCID 0000-0003-0262-1030
Johns Hopkins University · USNutramax Laboratories (United States) · US

Funding

Lewis B. and Dorothy Cullman Foundation --Nutramax Laboratories Consumer Care, Inc. --
6 · The paper itself

Abstract

We examined whether gastric acidity would affect the activity of myrosinase, co-delivered with glucoraphanin (GR), to convert GR to sulforaphane (SF). A broccoli seed and sprout extract (BSE) rich in GR and active myrosinase was delivered before and after participants began taking the anti-acid omeprazole, a potent proton pump inhibitor. Gastric acidity appears to attenuate GR bioavailability, as evidenced by more SF and its metabolites being excreted after participants started taking omeprazole. Enteric coating enhanced conversion of GR to SF, perhaps by sparing myrosinase from the acidity of the stomach. There were negligible effects of age, sex, ethnicity, BMI, vegetable consumption, and bowel movement frequency and quality. Greater body mass correlated with reduced conversion efficiency. Changes in the expression of 20 genes in peripheral blood mononuclear cells were evaluated as possible pharmacodynamic indicators. When grouped by their primary functions based on

Indexed as

BrassicaDietary SupplementsSeedlingsSeedsAdultAgedBiological AvailabilityDrug InteractionsFemaleGastric AcidGene Expression RegulationGlucosinolatesGlycoside HydrolasesHumansHydrogen-Ion ConcentrationImidoestersglucoraphaninGlucosinolatesGlycoside HydrolasesImidoestersIsothiocyanatesOmeprazoleOximesPlant ExtractsProton Pump InhibitorssulforaphaneSulfoxidesthioglucosidasechemopreventioncrucifernutritional supplementpharmacodynamicspharmacokinetics

Identifiers

PMID31261930
PMCPMC6682992
OpenAlexW2956016099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.