Evidence map›Paper›PMID 31261817›Full record

ArticleInternational journal of environmental research and public health2019

Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in Blood of Romanian Children Suspected of Having Autism Spectrum Disorder.

Manouchehr Hessabi, Mohammad H Rahbar, Iuliana Dobrescu, MacKinsey A Bach, Liana Kobylinska, Jan Bressler, Megan L Grove, Katherine A Loveland, Ilinca Mihailescu, Maria Cristina Nedelcu and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Manouchehr HessabiBiostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Mohammad H RahbarBiostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Iuliana DobrescuDepartment of Child and Adolescent Psychiatry, University of Medicine and Pharmacy of Carol Davila, Psychiatry Clinical Hospital Alexandru Obregia, Bucharest, sector 4, 041914, Romania.
MacKinsey A BachBiostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Liana KobylinskaDepartment of Child and Adolescent Psychiatry, University of Medicine and Pharmacy of Carol Davila, Psychiatry Clinical Hospital Alexandru Obregia, Bucharest, sector 4, 041914, Romania.
Jan BresslerDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Megan L GroveDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Katherine A LovelandDepartment of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.
Ilinca MihailescuDepartment of Child and Adolescent Psychiatry, University of Medicine and Pharmacy of Carol Davila, Psychiatry Clinical Hospital Alexandru Obregia, Bucharest, sector 4, 041914, Romania.
Maria Cristina NedelcuDepartment of Child and Adolescent Psychiatry, University of Medicine and Pharmacy of Carol Davila, Psychiatry Clinical Hospital Alexandru Obregia, Bucharest, sector 4, 041914, Romania.
Mihaela Georgeta MoisescuDepartment of Biophysics and Cellular Biotechnology, University of Medicine and Pharmacy of Carol Davila, Bucharest, sector 5, 050747, Romania.
Bogdan Mircea MateiDepartment of Biophysics and Cellular Biotechnology, University of Medicine and Pharmacy of Carol Davila, Bucharest, sector 5, 050747, Romania.
Christien Oktaviani MateiDepartment of Biophysics and Cellular Biotechnology, University of Medicine and Pharmacy of Carol Davila, Bucharest, sector 5, 050747, Romania.
Florina RadDepartment of Child and Adolescent Psychiatry, University of Medicine and Pharmacy of Carol Davila, Psychiatry Clinical Hospital Alexandru Obregia, Bucharest, sector 4, 041914, Romania. florina2rad@yahoo.com.
The University of Texas Health Science Center at Houston · USCarol Davila University of Medicine and Pharmacy · RO

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Training in Precision Environmental Health SciencesT32ES027801 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2018 to 2026
$2.8M
NCATS NIH HHS UL1 TR000371NCATS NIH HHS UL1 TR000445NIEHS NIH HHS T32 ES027801
6 · The paper itself

Abstract

Environmental exposure to lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) has been associated with neurodevelopmental disorders including autism spectrum disorder (ASD). We conducted a pilot study during May 2015-May 2107 to estimate blood concentrations of six metals (Pb, Hg, As, Cd, Mn, and Al) and identify their associated factors for children with ASD or suspected of having ASD in Romania. Sixty children, age 2-8 years, were administered versions of ADOS or ADI-R translated from English to Romanian. After assessment, 2-3 mL of blood was obtained and analyzed for the concentrations of the six metals. The mean age of children was 51.9 months and about 90% were male. More than half (65%) of the children were born in Bucharest. Over 90% of concentrations of As and Cd were below limits of detection. Geometric mean concentrations of Pb, Mn, Al, and Hg were 1.14 μg/dL, 10.84 μg/L, 14.44 μg/L, and 0.35 μg/L, respectively. Multivariable linear regression analysis revealed that children who were female, had less educated parents, exhibited pica, and ate cold breakfast (e.g., cereal), watermelon, and lamb had significantly higher concentrations of Pb compared to their respective referent categories (all

Indexed as

AluminumArsenicAutism Spectrum DisorderCadmiumChildChild, PreschoolEnvironmental ExposureFemaleHumansLeadLimit of DetectionMaleManganeseMercuryMetals, HeavyPilot ProjectsAluminumArsenicCadmiumLeadManganeseMercuryMetals, Heavyaluminumarsenicautism spectrum disordercadmiumleadmanganesemercuryRomania

Identifiers

PMID31261817
PMCPMC6651707
OpenAlexW2955881027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.