ArticleViruses2019
Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Feeding modifications and additional primary caregiver support for infants exposed to Zika virus or diagnosed with congenital Zika syndrome: a rapid review of the evidence.Tropical medicine & international health : TM & IH · 2020Pooled it
- Antiviral activity of eicosapentaenoic acid against zika virus and other enveloped viruses.Frontiers in pharmacology · 2025Article
- Viruses and Human Milk: Transmission or Protection?Advances in nutrition (Bethesda, Md.) · 2023Review
- Impact of time-temperature combinations on the anti-Cytomegalovirus activity and biological components of human milk.Pediatric research · 2023Article
- Article
- Article
- Brevinin-2GHk, a Peptide Derived from the Skin ofViruses · 2021Article
- Mother-to-Child Transmission of Arboviruses during Breastfeeding: From Epidemiology to Cellular Mechanisms.Viruses · 2021Review
- Seasonal Stability of SARS-CoV-2 in Biological Fluids.Pathogens (Basel, Switzerland) · 2021Article
- Seasonal stability of SARS-CoV-2 in biological fluids.bioRxiv : the preprint server for biology · 2021Article
- Best Practices for Human Milk Collection for COVID-19 Research.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2021Review
- Article
- Anti-Zika virus and anti-Usutu virus activity of human milk and its components.PLoS neglected tropical diseases · 2020Article
- An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection.Antiviral research · 2020Article
- Anti-Infective, Anti-Inflammatory, and Immunomodulatory Properties of Breast Milk Factors for the Protection of Infants in the Pandemic From COVID-19.Frontiers in public health · 2020Article
- Promoting and Protecting Human Milk and Breastfeeding in a COVID-19 World.Frontiers in pediatrics · 2020Review
- Evidence That Zika Virus Is Transmitted by Breastfeeding to Newborn A129 (Frontiers in microbiology · 2020Article
- Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator.Viruses · 2019Article
- Productive Infection of Mouse Mammary Glands and Human Mammary Epithelial Cells by Zika Virus.Viruses · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zika virus (ZIKV) causes congenital neurologic birth defects, notably microcephaly, and has been associated with other serious complications in adults. The virus has been detected in human breast milk and possible transmissions via breastfeeding have been reported. Breast milk is rich in nutrients and bio-active substances that might directly affect viral infectivity. Thus, here, we analyzed the effect of human breast milk on ZIKV infection. We observed that fresh human breast milk had no effect on ZIKV, but found that upon storage, milk effectively suppressed infection. The antiviral activity is present in the fat-containing cream fraction of milk and results in the destruction of the structural integrity of viral particles, thereby abrogating infectivity. The release of the factor is time dependent but varies with donors and incubation temperatures. The viral titer of milk that was spiked with ZIKV decreased considerably upon storage at 37 °C for 8 h, was lost entirely after 2 days of 4 °C storage, but was not affected at -20 °C. This suggests that cold storage of milk inactivates ZIKV and that the antiviral factor in milk may also be generated upon breastfeeding and limit this transmission route of ZIKV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.