ArticleAnimals : an open access journal from MDPI2019
Chronic Heat Stress Induces Acute Phase Responses and Serum Metabolome Changes in Finishing Pigs.
Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 79 citations in OpenAlex.
- Plasma metabolomics reveals distinct responses to acute and chronic heat stress in broilers.Poultry science · 2026Article
- Integrated Stress Physiology and Mitigation Strategies for Heat Stress in Layer Chickens-Review.Animals : an open access journal from MDPI · 2026Review
- Research progress on the mechanisms and intervention strategies of microbiota-gut-brain axis dysfunction under heat stress.Frontiers in physiology · 2026Review
- Effects of a Dietary Blend of Essential Oils, Capsaicin, and Yeast Metabolites on Performance, Physiological, Metabolism, and Immune Response of Heat-Stressed Pigs.Veterinary sciences · 2025Article
- Multi-Omics Analysis of Chronic Heat Stress-Induced Biological Effects, Liver Injury, and Heat Tolerance Mechanisms via Oxidative and Anti-Inflammatory Pathways in Early-Pregnancy Sows.Antioxidants (Basel, Switzerland) · 2025Article
- Heat Tolerance Differences Between Hu Sheep and Hu Crossbred Sheep in Microbial Community Structure and Metabolism.Metabolites · 2025Article
- Elevated levels of C-reactive protein and pig major acute phase protein in lame gestating sows.Frontiers in veterinary science · 2025Article
- Diagnostic utility of acute phase proteins and their ability to guide antibiotic usage in pigs, horses, and cattle: a mapping review.Acta veterinaria Scandinavica · 2024Review
- Genomic regions, candidate genes, and pleiotropic variants associated with physiological and anatomical indicators of heat stress response in lactating sows.BMC genomics · 2024Article
- Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine.BMC genomics · 2024Article
- Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows.Journal of animal science · 2024Article
- The effect of chronic, non-pathogenic maternal immune activation on offspring postnatal muscle and immune outcomes.Journal of animal science · 2024Article
- Investigating the impact of non-additive genetic effects in the estimation of variance components and genomic predictions for heat tolerance and performance traits in crossbred and purebred pig populations.BMC genomic data · 2023Article
- Article
- Effects of Hot Arid Environments on the Production Performance, Carcass Traits, and Fatty Acids Composition of Breast Meat in Broiler Chickens.Life (Basel, Switzerland) · 2023Article
- Metabolomics profiling to characterize cerebral ischemia-reperfusion injury in mice.Frontiers in pharmacology · 2023Article
- Filling gaps in animal welfare assessment through metabolomics.Frontiers in veterinary science · 2023Review
- Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Morphological Assessment and Biomarkers of Low-Grade, Chronic Intestinal Inflammation in Production Animals.Animals : an open access journal from MDPI · 2022Review
- Effects of chronic heat stress on the immunophenotyping of lymphocytes in immune organs of growing pigs.Journal of animal science · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Heat stress (HS) is a main environmental challenge affecting the animal welfare and production efficiency in pig industry. In recent years, numerous reports have studied the alterations in gene expressions and protein profiles in heat-stressed pigs. However, the use of metabolome to unravel adaptive mechanisms of finishing pig in response to chronic HS have not yet been elucidated. We aimed to investigate the effects of chronic HS on serum metabolome in finishing pigs, and to identify the biomarkers of heat stress. Pigs (n = 8 per treatment) were exposed to either thermal neutral (TN; 22 °C) or heat stress (HS, 30 °C) conditions for three weeks. Serum metabonomics of TN- and HS-treated pigs were compared using the GC-MS approach. Metabonomics analysis revealed that twenty-four metabolites had significantly different levels in TN compared to HS (variable importance in the projection values >1 and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.