ArticleJournal of clinical medicine2019
TNF-α/TNF-R System May Represent a Crucial Mediator of Proliferative Synovitis in Hemophilia A.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Biomarkers Involved in the Pathogenesis of Hemophilic Arthropathy.International journal of molecular sciences · 2024Review
- Ferroptosis: a new target for iron overload-induced hemophilic arthropathy synovitis.Annals of hematology · 2023Article
- Hemophilic arthropathy: Current knowledge and future perspectives.Journal of thrombosis and haemostasis : JTH · 2021Review
- Pathological mechanism of joint destruction in haemophilic arthropathy.Molecular biology reports · 2021Review
- Asymptomatic Joint Bleeding and Joint Health in Hemophilia: A Review of Variables, Methods, and Biomarkers.Journal of blood medicine · 2021Review
- Incapacitating pain from Tenofovir Induced Hypophosphatemic Osteomalacia in a Hemophilia Patient - A Case Report.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Unique inflammatory signature in haemophilic arthropathy: miRNA changes due to interaction between blood and fibroblast-like synoviocytes.Journal of cellular and molecular medicine · 2020Article
- Pathophysiological Role of Synovitis in Hemophilic Arthropathy Development: A Two-Hit Hypothesis.Frontiers in physiology · 2020Review
- A Translational Study of TNF-Alpha Antagonists as an Adjunctive Therapy for Preventing Hemophilic Arthropathy.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemophilic arthropathy (HA) typically begins with proliferative synovitis that shares some similarities with inflammatory arthritides, in which the proinflammatory cytokine tumor necrosis factor (TNF)-α has a crucial pathogenetic role. Inappropriate release of TNF-α was shown to contribute to arthropathy development following intra-articular bleeding in hemophilic mice. Here, we were interested in determining whether systemic levels of TNF-α and synovial tissue expression of the TNF-α/TNF receptor (TNF-R) system could be increased and related to joint damage in hemophilia A patients with severe HA. Serum levels of TNF-α measured by quantitative enzyme-linked immunosorbent assay (ELISA) were significantly increased in HA patients (
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