Evidence map›Paper›PMID 31261764›Full record

ArticleGenes2019

Genome-Wide Homozygosity Patterns and Evidence for Selection in a Set of European and Near Eastern Horse Breeds.

Gertrud Grilz-Seger, Markus Neuditschko, Anne Ricard, Brandon Velie, Gabriella Lindgren, Matjaz Mesarič, Marko Cotman, Michaela Horna, Max Dobretsberger, Gottfried Brem and 1 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 97 citations in OpenAlex.

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  14. Spotting the Pattern: A Review on White Coat Color in the Domestic Horse.Animals : an open access journal from MDPI · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 8 countries.

Gertrud Grilz-SegerInstitute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterinärplatz 1, 1210 Vienna, Austria. gertrud.grilz@vetmeduni.ac.at.
Markus NeuditschkoAgroscope, Swiss National Stud Farm, Les Longs Prés, CH-1580 Avenches, Switzerland. markus.neuditschko@agroscope.admin.ch.
Anne RicardUMR 1313 Génétique Animale et Biologie Intégrative, Institut National de la Recherche Agronomique, Domaine de Vilvert, Bat 211, 78352 Jouy-en-Josas, France. anne.ricard@inra.fr.
Brandon VelieDepartment of Animal Breeding & Genetics, Swedish University of Agricultural Sciences, Ulls väg 26, 750 07 Uppsala, Sweden. brandon.velie@sydney.edu.au.
Gabriella LindgrenDepartment of Animal Breeding & Genetics, Swedish University of Agricultural Sciences, Ulls väg 26, 750 07 Uppsala, Sweden. gabriella.lindgren@slu.se.
Matjaz MesaričClinic for Reproduction and Large Animals, University of Ljubljana, Veterinary, Faculty, Cesta v Mestni log 47, 1000 Ljubljana, Slovenia. Matjaz.Mesaric@vf.uni-lj.si.
Marko CotmanInstitute for Preclinical Sciences, University of Ljubljana, Veterinary Faculty, Gerbičeva 60, 1000 Ljubljana, Slovenia. marko.cotman@vf.uni-lj.si.
Michaela HornaDepartment of Animal Husbandry, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia. michaela.horna@post.sk.
Max DobretsbergerInstitute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterinärplatz 1, 1210 Vienna, Austria. maximilian.dobretsberger@vetmeduni.ac.at.
Gottfried BremInstitute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterinärplatz 1, 1210 Vienna, Austria. gottfried.brem@vetmeduni.ac.at.
Thomas DrumlInstitute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterinärplatz 1, 1210 Vienna, Austria. thomas.druml@vetmeduni.ac.at.
University of Veterinary Medicine Vienna · ATUniversity of Ljubljana · SIAgroscope · CHGénétique Animale et Biologie Intégrative · FRSlovak University of Agriculture in Nitra · SKSwedish University of Agricultural Sciences · SEThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intensive artificial and natural selection have shaped substantial variation among European horse breeds. Whereas most equine selection signature studies employ divergent genetic population structures in order to derive specific inter-breed targets of selection, we screened a total of 1476 horses originating from 12 breeds for the loss of genetic diversity by runs of homozygosity (ROH) utilizing a 670,000 single nucleotide polymorphism (SNP) genotyping array. Overlapping homozygous regions (ROH islands) indicating signatures of selection were identified by breed and similarities/dissimilarities between populations were evaluated. In the entire dataset, 180 ROH islands were identified, whilst 100 islands were breed specific, all other overlapped in 36 genomic regions with at least one ROH island of another breed. Furthermore, two ROH hot spots were determined at horse chromosome 3 (ECA3) and ECA11. Besides the confirmation of previously documented target genes involved in selection for coat color (

Indexed as

BreedingHomozygoteAgouti Signaling ProteinAnimalsBasic-Leucine Zipper Transcription FactorsCarrier ProteinsCell Adhesion MoleculesCytoskeletal ProteinsGene OntologyGenomeHMGA2 ProteinHomeodomain ProteinsHorsesInsulin-Like Growth Factor Binding ProteinsKeratins, Hair-SpecificMembrane ProteinsAgouti Signaling ProteinBasic-Leucine Zipper Transcription FactorsCarrier ProteinsCell Adhesion MoleculesCytoskeletal ProteinsHMGA2 ProteinHomeodomain ProteinsInsulin-Like Growth Factor Binding ProteinsKeratins, Hair-SpecificMembrane ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpharal GTP-Binding ProteinsRepressor ProteinsTranscription FactorsVesicular Transport Proteinsaltitude adaptationautophagybody sizecoat colorembryonic morphogenesisROH islandselection signature

Identifiers

PMID31261764
PMCPMC6679042
OpenAlexW2955263326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.