Evidence map›Paper›PMID 31261684›Full record

ReviewInternational journal of molecular sciences2019

Aristolochic Acid and Immunotherapy for Urothelial Carcinoma: Directions for unmet Needs.

Huang-Yu Yang, Chih-Chao Yang, Chao-Yi Wu, Li-Jen Wang, Kun-Lin Lu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Huang-Yu YangDepartment of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. hyyang01@gmail.com.ORCID 0000-0001-6826-9717
Chih-Chao YangDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chao-Yi WuDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Li-Jen WangDepartment of Medical Imaging and Radiological Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Kun-Lin LuDepartment of Medical Education, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan. johnlu710999@gmail.com.
Chang Gung University · TWChang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital CORPG3F0131-3
6 · The paper itself

Abstract

Urothelial carcinoma of the bladder (UCB) and upper tracts (UTUC) used to share management with similar principles. However, their genetic and epigenetic differences along with different responses to immunotherapy were recently identified, which are reminiscent of their distinct etiologies. Different from the variety of environmental factors relating to UCB, UTUC is best known for its close relationship with exposure to aristolochic acid (AA). AA is believed to cause its carcinogenicity through forming DNA adducts of deoxyadenosine-aristolactam, as well as A:T → T:A transversions in the

Indexed as

AnimalsAristolochic AcidsCarcinogensCarcinomaHumansImmunotherapyUrinary Bladder NeoplasmsUrotheliumaristolochic acid IAristolochic AcidsCarcinogensaristolochic acidimmune checkpoint inhibitorsmutation loadupper tract urothelial carcinomaurothelial carcinoma of the bladder

Identifiers

PMID31261684
PMCPMC6650931
OpenAlexW2954300481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.