Evidence map›Paper›PMID 31261545›Full record

ArticleMedicine2019

Fecal microbiota transplantation to treat Parkinson's disease with constipation: A case report.

Hongli Huang, Haoming Xu, Qingling Luo, Jie He, Mengyan Li, Huiting Chen, Wenjuan Tang, Yuqiang Nie, Yongjian Zhou

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07597421 (Fecal Microbiota Transplantation for the Treatment of Patients With Parkinson's Disease.), which is not on this map. Cited by 125 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 3 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07597421 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Fecal Microbiota Transplantation for the Treatment of Patients With Parkinson's Disease.

TypeinterventionalSponsorChang Gung Memorial HospitalRan2026 to 2029Enrolled58ConditionsParkinson's DiseaseArmsFecal microbiota transplantation, Not received Fecal microbiota transplantation
3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 3 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hongli HuangDepartment of Gastroenterology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong.
Haoming XuDepartment of Gastroenterology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong.
Qingling LuoDepartment of Gastroenterology, Guangzhou Digestive Disease Center.
Jie HeDepartment of Gastroenterology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong.
Mengyan LiDepartment of Neurology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Huiting ChenDepartment of Gastroenterology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong.
Wenjuan TangDepartment of Gastroenterology, Guangzhou Digestive Disease Center.
Yuqiang NieDepartment of Gastroenterology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong.
Yongjian ZhouDepartment of Gastroenterology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong.
Guangzhou Medical University · CNSouth China University of Technology · CNGuangzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleFecal microbiota transplantation (FMT) is recognized as an emerging treatment through reconstruction of gut microbiota. Parkinson's disease is a neurodegenerative disorder, which is accompanied by constipation. Here we first reported a patient with Parkinson's disease and constipation that were obviously relieved after FMT. PATIENT CONCERNS: A 71-year-old male patient presented with 7 years of resting tremor, bradykinesia (first inflicted the upper limbs and subsequently spread to lower limbs), and intractable constipation (defecation needing more than 30 minutes). DIAGNOSES: Parkinson's disease for 7 years; constipation >3 years.

interventionsThe patient had used madopar, pramipexole, and amantadine for anti-Parkinson and showed partially mitigation while laxative therapy for constipation failed. Finally FMT was performed. OUTCOMES: The patient successfully defecated within 5 minutes and maintained daily unobstructed defecation until the end of follow-up. The patient's tremor in legs almost disappeared at 1 week after FMT but recurred in the right lower extremity at 2 months after FMT. LESSONS: Gut microbiota reconstruction may have therapeutic effects for Parkinson's disease patients, especially those who have gastrointestinal symptoms and limited treatment choices.

Indexed as

Fecal Microbiota TransplantationAgedConstipationHumansMaleParkinson Disease

Identifiers

PMID31261545
PMCPMC6616439
OpenAlexW2953625730

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.