ArticleMedicine2019
Comparisons of therapeutic outcomes in patients with nonampullary duodenal neuroendocrine tumors (NADNETs): A multicenter retrospective study.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors for lymph node metastasis in duodenal neuroendocrine tumors: a systematic review and meta-analysis.Journal of gastroenterology · 2025Pooled it
- Successful endoscopic resection of large duodenal bulb carcinoid tumor: a case report.Annals of medicine and surgery (2012) · 2026Article
- Comparison Between endoscopic submucosal dissection and laparoscopic endoscopic cooperative surgery for non-ampullary duodenal neuroendocrine tumors: a single-center retrospective cohort study.International journal of surgery (London, England) · 2026Article
- Long-Term Outcomes in Patients With Non-Ampullary Duodenal Neuroendocrine Tumors.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- How Should Incidentally Detected Non-Ampullary Duodenal Neuroendocrine Tumors Be Treated?The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Endoscopic resection for non-ampullary duodenal subepithelial lesions: a retrospective cohort study.International journal of colorectal disease · 2024Article
- Treatment outcomes of endoscopic resection for nonampullary duodenal neuroendocrine tumors.Journal of gastrointestinal oncology · 2024Article
- Endoscopic Resection for Duodenal Neuroendocrine Neoplasms between 10 and 20 mm-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Review
- Duodenal neuroendocrine tumors: Short-term outcomes of endoscopic submucosal dissection performed in the Western setting.Endoscopy international open · 2023Article
- Long-term outcomes of endoscopic resection for duodenal neuroendocrine tumors.Scientific reports · 2023Article
- Current status of the role of endoscopy in evaluation and management of gastrointestinal and pancreatic neuroendocrine tumors.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Review
- Development and Validation of Prognostic Nomograms for Periampullary Neuroendocrine Neoplasms: A SEER Database Analysis.Current oncology (Toronto, Ont.) · 2022Article
- Safety and efficacy of surgical and endoscopic resection in the treatment of duodenal subepithelial lesions.Surgical endoscopy · 2022Article
- Current updates and future directions in diagnosis and management of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastrointestinal endoscopy · 2022Review
- Management of Duodenal Neuroendocrine Tumors: Surgical versus Endoscopic Mucosal Resection.Annals of surgical oncology · 2022Article
- The Role of Endoscopy in Small Bowel Neuroendocrine Tumors.Clinical endoscopy · 2021Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Duodenal neuroendocrine tumors (DNETs) are rare tumors that are occasionally found during upper endoscopies. The incidence of DNETs is increasing, although the data regarding treatment outcomes are insufficient. The aim of this study was to evaluate the treatment outcomes in patients with nonampullary DNETs who underwent endoscopic resection or surgery. We evaluated the medical records of patients who were diagnosed with nonampullary DNETs from 2004 to 2017 in 7 university hospitals. We retrospectively analyzed clinical characteristics and compared therapeutic outcomes based on the endoscopic lesion size and treatment method. We ultimately enrolled 60 patients with nonampullary DNETs who underwent endoscopic and surgical treatments. In the endoscopic treatment group, the en bloc resection, endoscopic complete resection (CR) and pathologic CR rates were 88%, 92%, and 50%, respectively. The endoscopic treatment group was divided into 3 subgroups based on the lesion size (1-5 mm, 6-10 mm, and ≥11 mm). The pathologic CR rate was significantly lower in the subgroup with a lesion size ≥11 mm (0%, P = .003) than those in the other 2 subgroups. Lymphovascular invasion occurred significantly more frequently (33.3%, P = .043) among those with a lesion size ≥11 mm. The pathologic CR rate in the surgical treatment group was higher (90.9%) than that in the endoscopic treatment group (50%, P = .017). Surgical treatment appears to be a more appropriate choice because of the risks of incomplete resection and lymphovascular invasion after endoscopic treatment for lesions larger than 11 mm.
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