ArticleMedicine2019
Acute onset neurological symptoms in Wilson disease after traumatic, surgical or emotional events: A cross-sectional study.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Cerebellar Contributions to Cognitive Affective Function and Postural Tremor in Neurological Wilson's Disease.Cerebellum (London, England) · 2026Article
- Emotion-tremor coupling in Wilson's disease: EEG microstate C as a marker of salience network dysregulation.Orphanet journal of rare diseases · 2026Article
- Assessment of neurological symptoms and associated factors in patients with Wilson's disease in Southwest China.Orphanet journal of rare diseases · 2025Article
- Evaluation of salivary ceruloplasmin for the diagnosis of Wilson's disease.Scientific reports · 2025Article
- From copper homeostasis to cuproptosis: a new perspective on CNS immune regulation and neurodegenerative diseases.Frontiers in neurology · 2025Review
- Usefulness of the Leipzig Score in the Diagnosis of Wilson's Disease - A Diagnostically Challenging Case Report.International medical case reports journal · 2024Article
- Analysis of risk factors for neurological symptoms in patients with purely hepatic Wilson's disease at diagnosis.BMC neurology · 2023Article
- A rare giant intracranial arachnoid cyst confused the diagnosis and treatment of Wilson disease.Translational neuroscience · 2022Article
- Acute Movement Disorders in Childhood.Journal of clinical medicine · 2021Review
- Management Perspective of Wilson's Disease: Early Diagnosis and Individualized Therapy.Current neuropharmacology · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute onset neurological symptoms evoked by traumatic, surgical, or emotional events in Wilson disease (WD) have never been reported and its clinical characteristics are unclear.We aimed to summarize the clinical characteristics of a special WD whose neurological symptoms acutely developed after traumatic, surgical, or emotional events.Retrospective pilot study.Thirty-one patients who had acute onset neurological symptom as an initial presentation of WD or a new presentation of hepatic WD after mild trauma, surgery, or emotional events were retrospectively studied. All patients were followed for half to 1 year after regular anti-copper treatment.The averaged latency for neurological symptom presentation was 2.79 ± 1.21 hours. The most frequent neurological symptoms were tremor (74%) and basal ganglia (BG) lesions were detected on magnetic resonance imaging in all patients. Lesions in other regions were much less frequently detected. Neurological symptom score and its recovery after treatment were correlated with lesion location: BG area and BG plus other brain areas. Neurological symptoms improved in 21 patients who received timely anti-copper treatment but continued to deteriorate in 6 patients who did not accept regular anti-copper treatment for delayed diagnosis.A diagnosis of WD should be considered when adolescents or adults experience acute presentation of extrapyramidal systems after traumatic, surgical, or emotional stimulation. Timely anti-copper therapy usually gives rise to an excellent prognosis.
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