Evidence map›Paper›PMID 31261373›Full record

Trial reportPediatric research2020

Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic-ischemic encephalopathy.

Yvonne W Wu, Amy M Goodman, Taeun Chang, Sarah B Mulkey, Fernando F Gonzalez, Dennis E Mayock, Sandra E Juul, Amit M Mathur, Krisa Van Meurs, Robert C McKinstry and 1 more

Registry-linked trialAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01913340 (Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes Study), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01913340 phase1 / phase2completednot on this map

Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2013 to 2016Enrolled50ConditionsHypoxic-ischemic Encephalopathy, Neonatal Encephalopathy, Birth AsphyxiaArmsErythropoietin, Normal saline
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Maternal-placental timing profiles of hypoxic-ischemic insult and association with prognosis in neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
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  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
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  14. Article
  15. Placental contribution to neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021
    Review
  16. Article
  17. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Yvonne W WuDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA. WuY@ucsf.edu.
Amy M GoodmanDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Taeun ChangDepartment of Neurology, Children's National Health Systems, Washington, DC, USA.
Sarah B MulkeyDepartment of Neurology, Children's National Health Systems, Washington, DC, USA.
Fernando F GonzalezDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Dennis E MayockDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Sandra E JuulDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Amit M MathurDepartments of Pediatrics, Washington University, St. Louis, MO, USA.
Krisa Van MeursDepartment of Pediatrics, Stanford University, Palo Alto, CA, USA.
Robert C McKinstryDepartment of Radiology, Washington University, St. Louis, MO, USA.
Raymond W RedlineDepartment of Pathology, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA.
University of California, San Francisco · USUniversity of Washington · USWashington University in St. Louis · USChildren's National · USGeorge Washington University · USStanford University · USUniversity Hospitals of Cleveland · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNewborns with hypoxic-ischemic encephalopathy (HIE) may exhibit abnormalities on placental histology. In this phase II clinical trial ancillary study, we hypothesized that placental abnormalities correlate with MRI brain injury and with response to treatment.

methodsFifty newborns with moderate/severe encephalopathy who received hypothermia were enrolled in a double-blind, placebo-controlled trial of erythropoietin for HIE. A study pathologist reviewed all available clinical pathology reports to determine the presence of chronic abnormalities and acute chorioamnionitis. Neonatal brain MRIs were scored using a validated HIE scoring system.

resultsPlacental abnormalities in 19 of the 35 (54%) patients with available pathology reports included chronic changes (N = 13), acute chorioamnionitis (N = 9), or both (N = 3). MRI subcortical brain injury was less common in infants with a placental abnormality (26 vs. 69%, P = 0.02). Erythropoietin treatment was associated with a lower global brain injury score (median 2.0 vs. 11.5, P = 0.003) and lower rate of subcortical brain injury (33 vs. 90%, P = 0.01) among patients with no chronic placental abnormality but not in patients whose placentas harbored a chronic abnormality.

conclusionErythropoietin treatment was associated with less brain injury only in patients whose placentas exhibited no chronic histologic changes. Placentas may provide clues to treatment response in HIE.

Indexed as

BrainBrain DiseasesDouble-Blind MethodErythropoietinFemaleHumansHypothermia, InducedHypoxia-Ischemia, BrainInfant, NewbornMagnetic Resonance ImagingMalePlacentaPregnancyEPO protein, humanErythropoietin

Identifiers

PMID31261373
OpenAlexW2954107975

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.