ArticleInvestigative radiology2019
Magnetization Transfer Imaging Is Unaffected by Decreases in Renal Perfusion in Swine.
Article in Investigative radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Progress of functional magnetic resonance imaging in the assessment of transplanted kidney function.Renal failure · 2025Review
- Combining Multifrequency Magnetic Resonance Elastography With Automatic Segmentation to Assess Renal Function in Patients With Chronic Kidney Disease.Journal of magnetic resonance imaging : JMRI · 2025Article
- Contemporary and Emerging MRI Strategies for Assessing Kidney Allograft Complications: Arterial Stenosis and Parenchymal Injury, From theAJR. American journal of roentgenology · 2024Review
- Advances in imaging techniques to assess kidney fibrosis.Renal failure · 2023Review
- Severity of polycystic kidney disease revealed by multiparametric MRI.Magnetic resonance in medicine · 2023Article
- Evaluation of Renal Fibrosis Using Magnetization Transfer Imaging at 1.5T and 3T in a Porcine Model of Renal Artery Stenosis.Journal of clinical medicine · 2023Article
- Multiparametric magnetic resonance imaging in diagnosis of long-term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice.NMR in biomedicine · 2022Article
- Reliable Assessment of Swine Renal Fibrosis Using Quantitative Magnetization Transfer Imaging.Investigative radiology · 2022Article
- Clinical and experimental approaches for imaging of acute kidney injury.Clinical and experimental nephrology · 2021Review
- Quantitative Magnetization Transfer Detects Renal Fibrosis in Murine Kidneys With Renal Artery Stenosis.Journal of magnetic resonance imaging : JMRI · 2020Article
- Mesenchymal Stem/Stromal Cells and their Extracellular Vesicle Progeny Decrease Injury in Poststenotic Swine Kidney Through Different Mechanisms.Stem cells and development · 2020Article
- MRI for diagnosis of post-renal transplant complications: current state-of-the-art and future perspectives.Magma (New York, N.Y.) · 2020Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesMultiparametric renal magnetic resonance imaging (MRI), including diffusion-weighted imaging, magnetic resonance elastography, and magnetization transfer imaging (MTI), is valuable in the noninvasive assessment of renal fibrosis. However, hemodynamic changes in diseased kidneys may impede their ability to measure renal fibrosis. Because MTI assesses directly tissue content of macromolecules, we test the hypothesis that MTI would be insensitive to renal hemodynamic changes in swine kidneys with acute graded ischemia. MATERIALS AND
methodsSeven domestic pigs underwent placement of an inflatable silicone cuff around the right renal artery to induce graded renal ischemia. Multiparametric MRI was performed at baseline, 50%, 75%, and 100% renal artery stenosis as well as reperfusion. Measurements included regional perfusion, R2*, apparent diffusion coefficient (ADC), stiffness, and magnetization transfer ratio (MTR) using arterial spin-labeled MRI, blood oxygenation-dependent MRI, diffusion-weighted imaging, magnetic resonance elastography, and MTI, respectively. Histology was performed to rule out renal fibrosis.
resultsDuring graded ischemia, decreases in renal perfusion were accompanied with elevated R2*, decreased ADC, and stiffness, whereas no statistically significant changes were observed in the MTR. No fibrosis was detected by histology. After release of the obstruction, renal perfusion showed only partial recovery, associated with return of kidney R2*, ADC, and stiffness to baseline levels, whereas cortical MTR decreased slightly.
conclusionsRenal MTI is insensitive to decreases in renal perfusion and may offer reliable assessment of renal structural changes.
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