ArticleCornea2019
Structural Differences in Meibum From Donors After Hematopoietic Stem Cell Transplantations.
Article in Cornea, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy.Investigative ophthalmology & visual science · 2026Article
- Alteration of Meibum Lipidomics Profiling in Patients With Chronic Ocular Graft-Versus-Host Disease.Investigative ophthalmology & visual science · 2023Article
- Meibum Lipid Composition and Conformation in Parkinsonism.EC ophthalmology · 2021Article
- Meibum lipid hydrocarbon chain branching and rheology after hematopoietic stem cell transplantation.Biochemistry and biophysics reports · 2020Article
- Concentration dependent cholesteryl-ester and wax-ester structural relationships and meibomian gland dysfunction.Biochemistry and biophysics reports · 2020Article
- Article
- Lipid Saturation and the Rheology of Human Tear Lipids.International journal of molecular sciences · 2019Article
- The optimum temperature for the heat therapy for meibomian gland dysfunction.The ocular surface · 2019Article
- New approaches for diagnosis of dry eye disease.International journal of ophthalmology · 2019Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeMeibum is considered to be a key component of tears that serve to protect the eye, and conformational changes in meibum have not been studied extensively within the population of patients who had hematopoietic stem cell transplantation (HSCT). The aim of this study was to determine possible lipid conformational changes in the meibum of patients who had HSCT.
methodsParticipants who had HSCT were randomly sampled for this prospective comparative study. Control participants did not have dry eye or had not undergone allogeneic or autologous stem cell transplantation. Fourier-transform infrared spectroscopy was used to measure meibum phase transition.
resultsMeibum was collected from both eyes of 36 donors without dry eye (Mc) and from 22 patients who had undergone HSCT (MHSCT). There were no significant differences between the phase transition parameters based on gender or race. The following were the significant differences (P < 0.0001) between the parameters for Mc compared with MHSCT : lipid order (% trans) at 33.4°C increased from 40 (1) to 54 (2), cooperativity decreased from 7.9 (0.4) to 5.4 (0.3), the phase transition temperature (C) increased from 30.3 (0.4) to 34.2 (0.9), and the magnitude of the phase transition (cm) increased from 4.0 (0.1) to 4.7 (0.5) (standard error of the mean).
conclusionsConformational and thermodynamic differences were observed between Mc and MHSCT. The changes observed in the lipid conformation of meibum from patients receiving HSCTs suggest that meibum composition changes after stem cell transplantation, and clinicians should consider treating the meibomian glands to improve the ocular surface.
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