Evidence map›Paper›PMID 31261154›Full record

ArticleFetal diagnosis and therapy2020

Leukocyte Counts and Other Hematological Values in Twin-Twin Transfusion Syndrome and Twin Anemia-Polycythemia Sequence.

G Laurien Visser, Lisanne S A Tollenaar, Vincent Bekker, Arjan B Te Pas, Arjan C Lankester, Dick Oepkes, Enrico Lopriore, Lianne Verbeek

Open access · hybridAbstract readComparative StudyTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Fetal diagnosis and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

G Laurien VisserDivision of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Lisanne S A TollenaarDepartment of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.
Vincent BekkerDivision of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Arjan B Te PasDivision of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Arjan C LankesterDivision of Immunology, Hematology and Stem Cell Transplantation, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Dick OepkesDepartment of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.
Enrico LoprioreDivision of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Lianne VerbeekDivision of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands, l.i.verbeek@lumc.nl.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the differences in leukocyte counts at birth between donors and recipients with twin-twin transfusion syndrome (TTTS) or twin anemia-polycythemia sequence (TAPS).

methodsWe performed a retrospective cohort study in monochorionic twin pairs with TTTS or TAPS. TTTS and TAPS cases treated with fetoscopic laser surgery were excluded. Primary outcome was the difference in leukocyte levels at birth between donor and recipient twins and the presence of leukopenia (defined as leukocyte count <4 × 109/L). Secondary outcomes included early-onset sepsis, necrotizing enterocolitis, use of antibiotics during admission, and neonatal mortality.

resultsWe included 99 twins pairs, of which 61 twin pairs were affected by TAPS and 38 twin pairs by TTTS. The mean leukocyte count at birth in donors and recipients was 7.5 × 109/L versus 7.4 × 109/L (p = 0.936), respectively. Leukopenia was significantly more common in donor twins compared to recipient twins (7.1% [7/99] vs. 0% [0/99], p = 0.016). Of the 7 donors with leukopenia, 6 were affected by TAPS and 1 by TTTS. Overall, donors were more often affected by early-onset sepsis than recipients, 23.7% (23/97) versus 13% (13.7/95) (p = 0.049), respectively.

conclusionsLeukocyte counts at birth in twins with TTTS or TAPS are similar between donors and recipients, but TAPS donors are at an increased risk of leukopenia. Overall, TTTS and TAPS donors seem to be at an increased risk of early-onset neonatal sepsis compared to recipient twins.

Indexed as

Twins, MonozygoticAnemiaBiomarkersFemaleFetofetal TransfusionHumansInfantInfant, NewbornLeukocyte CountLeukopeniaNeonatal SepsisPolycythemiaPredictive Value of TestsPregnancyPrognosisRetrospective StudiesBiomarkersLeukocyte countLeukopeniaMonochorionic twinsTwin anemia-polycythemia sequenceTwin-twin transfusion syndrome

Identifiers

PMID31261154
PMCPMC7050663
OpenAlexW2956128633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.