Evidence map›Paper›PMID 31260791›Full record

ArticleContemporary clinical trials2019

Rationale and design of the regimen education and messaging in diabetes (REMinD) trial.

Rachel O'Conor, Marina Arvanitis, Guisselle Wismer, Lauren Opsasnick, Angela Sanchez Muñoz, Joseph Kannry, Jenny J Lin, Darren Kaiser, Mary J Kwasny, Stephen D Persell and 4 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rachel O'ConorDivision of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America. Electronic address: r-oconor@northwestern.edu.
Marina ArvanitisDivision of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Guisselle WismerDivision of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Lauren OpsasnickDivision of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Angela Sanchez MuñozDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Joseph KannryDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Jenny J LinDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Darren KaiserDivision of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Mary J KwasnyDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Stephen D PersellDivision of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Ruth ParkerDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, United States of America.
Alastair J J WoodDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America.
Alex D FedermanDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Michael S WolfDivision of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
EHR-based Universal Medication Schedule to Improve Adherence to Complex RegimensR01NR015444 · NINR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FEDERMAN, ALEX D, WOLF, MICHAEL S · 2016 to 2020
$2.9M
NCATS NIH HHS UL1 TR001422NINR NIH HHS R01 NR015444
6 · The paper itself

Abstract

backgroundIndividuals with type 2 diabetes manage complex multi-drug regimens, but nearly half of all patients do not consistently take the dose prescribed for them, and therefore may not receive the full potential therapeutic benefit. Both patient and health system factors contribute to achieving and maintaining medication adherence. To determine if patients with type 2 diabetes who are concurrently managing other chronic conditions could improve their adherence, we devised and are testing a multifaceted, primary care-based strategy to provide health literacy-appropriate and language concordant regimen information, guidance and reminders.

objectiveWe are testing the effectiveness of an electronic health record (EHR) based strategy and short message service (SMS) text reminders to help patients with type 2 diabetes adhere to their medications.

methodsWe are conducting a 3-arm, multi-site trial to test and compare the effectiveness of the EHR, and EHR + SMS text reminder strategies compared to usual care on medication adherence. Our goal is to enroll a total of 900 English or Spanish-speaking patients with type 2 diabetes and hemoglobin A1C value ≥7.5%. Enrolled participants will complete interviews at baseline and 3 and 6 months following their baseline interview.

conclusionsOur trial is evaluating practical, clinic-based, scalable, evidence-based solutions for patients with type 2 diabetes managing complex medication regimens. Our findings will evaluate strategies that can be implemented broadly in primary care practices, and programmed as defaults within EHRs to support appropriate medication adherence to allow the widespread implementation of those strategies.

Indexed as

Medication AdherenceText MessagingAdultDiabetes Mellitus, Type 2Electronic Health RecordsFemaleHumansHypoglycemic AgentsInterviews as TopicMaleMulticenter Studies as TopicPatient Education as TopicPrimary Health CareRandomized Controlled Trials as TopicHypoglycemic AgentsDiabetesElectronic health recordHealth literacyMedication adherencePrimary careText messaging

Identifiers

PMID31260791
PMCPMC6642855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.