Evidence map›Paper›PMID 31260717›Full record

ArticleExperimental hematology2019

Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465).

Hiro Tatetsu, Myriam Armant, Fei Wang, Chong Gao, Shikiko Ueno, Xi Tian, Alex Federation, Jun Qi, James Bradner, Daniel G Tenen and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Experimental hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Hiro TatetsuDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Myriam ArmantTrans Lab, Children's Hospital Boston, Boston, Massachusetts.
Fei WangDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Chong GaoDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Shikiko UenoDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Xi TianDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Alex FederationDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Jun QiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
James BradnerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Daniel G TenenCancer Science Institute of Singapore, National University of Singapore Centre for Translational Medicine, Singapore; Harvard Stem Cell Institute, Boston, Massachusetts.
Li ChaiDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: lchai@partners.org.
Brigham and Women's Hospital · USDana-Farber Cancer Institute · USBoston Children's Museum · USNational University of Singapore · SG

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6M
Transcription regulation in hematopoiesisP01HL095489 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PARK, SHINYOUNG · 2010 to 2020
$20.1M
Mechanisms of regulation by RNA in acute myeloid leukemiaR35CA197697 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TENEN, DANIEL G · 2015 to 2021
$7.1M
NCI NIH HHS R35 CA197697NHLBI NIH HHS P01 HL095489NHLBI NIH HHS P01 HL131477
6 · The paper itself

Abstract

Currently, there is a growing need for culturing hematopoietic stem/progenitor cells (HSPCs) in vitro for various clinical applications including gene therapy. Compared with cord blood (CB) CD34

Indexed as

Cell Culture TechniquesHematopoietic Stem Cell MobilizationPeripheral Blood Stem Cell TransplantationAnimalsGATA2 Transcription FactorGraft SurvivalHeterograftsHistone Deacetylase InhibitorsHumansHydroxamic AcidsMiceMice, Inbred NODMice, SCIDMice, TransgenicPeripheral Blood Stem CellsSignal TransductionGATA2 protein, humanGATA2 Transcription FactorHistone Deacetylase InhibitorsHydroxamic AcidsSALL4 protein, humanTranscription Factorstrichostatin A

Identifiers

PMID31260717
PMCPMC6719293
OpenAlexW2954454590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.