ArticleThe Journal of allergy and clinical immunology2019
Clinical onset of atopic eczema: Results from 2 nationally representative British birth cohorts followed through midlife.
Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Educational and psychological interventions for managing atopic dermatitis (eczema).The Cochrane database of systematic reviews · 2024Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2022Pooled it
- 12-month prevalence of atopic dermatitis in resource-rich countries: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2021Pooled it
- Partner bereavement and risk of psoriasis and atopic eczema: cohort studies in the U.K. and Denmark.The British journal of dermatology · 2020Pooled it
- Atopic Dermatitis and Markers of Early Cardiovascular Risk in Children and Adolescents.JAMA network open · 2026Article
- Incidence and Remission of Atopic Dermatitis in a German Birth Cohort.JAMA network open · 2025Observational
- Identification of atopic dermatitis-associated diseases based on the National health and nutrition examination survey (NHANES) 2013-2018.Scientific reports · 2025Article
- The burden of atopic dermatitis in Portuguese patients: an observational study.Scientific reports · 2024Observational
- Incident Asthma, Asthma Exacerbations, and Asthma-Related Hospitalizations in Patients With Atopic Dermatitis.The journal of allergy and clinical immunology. In practice · 2024Article
- Comparative efficacy of combined antihistamine and montelukast therapy in adult patients with atopic dermatitis.Postepy dermatologii i alergologii · 2024Article
- [Eczema and its treatment in older adults].Dermatologie (Heidelberg, Germany) · 2023Review
- Article
- A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis.Frontiers in genetics · 2023Article
- From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine.Journal of personalized medicine · 2022Review
- Prevalence and characteristics of atopic dermatitis among young adult females and males-report from the Swedish population-based study BAMSE.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Sex-specific developmental trajectories of eczema from infancy to age 26 years: A birth cohort study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- Atopic Eczema: Pathophysiological Findings as the Beginning of a New Era of Therapeutic Options.Handbook of experimental pharmacology · 2022Article
- Review
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundAtopic eczema onset is described primarily in early childhood, and the frequency and characteristics of adult-onset disease remain controversial.
objectiveWe sought to determine the proportion of subjects who report atopic eczema symptoms between birth and midadulthood and to examine demographic, immunologic, and genetic factors associated with period of symptom onset.
methodsWe conducted a longitudinal study using data from 2 nationally representative community-based birth cohorts from the United Kingdom: the British Cohort Studies 1958 and 1970. Subjects were followed from birth through age 42 to 50 years. The primary outcome was the age period of self-reported atopic eczema symptom onset based on repeated measures of self-reported atopic eczema at each survey wave.
resultsThe annual period prevalence of atopic eczema ranged from 5% to 15% in 2 cohorts of more than 17,000 participants each followed from birth through middle age. There was no clear trend in prevalence by age, and among adults reporting active atopic eczema during a given year, only 38% had symptom onset reported in childhood. When compared with subjects whose eczema started in childhood, those with adult-onset disease were more likely to be women, from Scotland or Northern England, of lower childhood socioeconomic group, smokers in adulthood, and less likely to have a history of asthma. In a subanalysis using data from the 1958 cohort only, genetic mutations previously associated with atopic eczema, including filaggrin-null mutations, and allergen-specific IgE were more common among those with childhood-onset disease.
conclusionRates of self-reported atopic eczema remain high after childhood, and adult-onset atopic eczema has different risk factor associations than childhood-onset eczema.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.