Evidence map›Paper›PMID 31260634›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality.

Morayo G Adebiyi, Zhaoyang Zhao, Youqiong Ye, Jeanne Manalo, Yue Hong, Cheng Chi Lee, Wa Xian, Frank McKeon, Rachel Culp-Hill, Angelo D' Alessandro and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Inhibition of Circadian Rhythm GeneEnvironment & health (Washington, D.C.) · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Morayo G AdebiyiDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Zhaoyang ZhaoDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Youqiong YeDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Jeanne ManaloDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Yue HongDepartment of Biology and Biochemistry, The University of Houston, Houston, Texas, USA.
Cheng Chi LeeDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Wa XianThe Institute of Molecular Medicine, The University of Texas McGovern Medical School, Houston, Texas, USA.
Frank McKeonDepartment of Biology and Biochemistry, The University of Houston, Houston, Texas, USA.
Rachel Culp-HillDepartment of Biochemistry and Molecular Genetics, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Angelo D' AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Rodney E KellemsDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Seung-Hee YooDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Leng HanDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
Yang XiaDepartment of Biochemistry and Molecular Biology, The University of Texas McGovern Medical School, Houston, Texas, USA.
The University of Texas Health Science Center at Houston · USThe University of Texas Health Science Center · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Houston · US

Funding

Trangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLACKBURN, MICHAEL R · 2013 to 2017
$10.0M
Erythrocyte metabolomic profiling reveals new insight and approaches to promote oxygen deliveryR01HL136969 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI PUTKEY, JOHN ANTHONY, ZHANG, YUJIN · 2017 to 2019
$1.5M
Metabolites, Sickle Cell Disease, and Novel TherapeuticsR01HL113574 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2013 to 2016
$1.5M
Molecular insight of erythrocyte hypoxic metabolic reprogramming in chronic kidney diseaseR01HL137990 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2017 to 2018
$989k
NHLBI NIH HHS P01 HL114457NHLBI NIH HHS R01 HL113574NHLBI NIH HHS R01 HL136969NHLBI NIH HHS R01 HL137990
6 · The paper itself

Abstract

The circadian clock is important for cellular and organ function. However, its function in sickle cell disease (SCD), a life-threatening hemolytic disorder, remains unknown. Here, we performed an unbiased microarray screen, which revealed significantly altered expression of circadian rhythmic genes, inflammatory response genes, and iron metabolic genes in SCD Berkeley transgenic mouse lungs compared with controls. Given the vital role of period 2 (Per2) in the core clock and the unrecognized role of Per2 in SCD, we transplanted the bone marrow (BM) of SCD mice to

Indexed as

Circadian ClocksAnemia, Sickle CellAnimalsBone Marrow TransplantationCircadian RhythmGene Expression ProfilingIron OverloadMiceMice, KnockoutPeriod Circadian ProteinsPneumoniaPer1 protein, mousePer2 protein, mousePeriod Circadian Proteinscircadian clockheme-iron metabolismlung

Identifiers

PMID31260634
PMCPMC6988849
OpenAlexW2954475687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.