ArticleDepression and anxiety2019
Association between posttraumatic stress disorder severity and amygdala habituation to fearful stimuli.
Article in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Neural Correlates of Maternal Posttraumatic Stress in the First Postpartum Year: Blunted Salience and Prefrontal Responses to Infant Distress.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Emotion-specific amygdala habituation in treatment-referred young adults with antisocial histories: links with internalizing and externalizing symptoms and future recidivism.Neuroimage. Reports · 2026Article
- Ketogenic therapy as a potential novel treatment approach for PTSD: an integrative review and proposed mechanistic model.Frontiers in psychiatry · 2026Review
- The dynamic features of long-term habituation of negative emotions: evidence from eye-tracking and hypothalamic-pituitary-adrenal axis research.Frontiers in psychiatry · 2026Article
- Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Racial Differences in Biopsychosocial Pathways to Tobacco and Marijuana Use Among Youth.Journal of racial and ethnic health disparities · 2025Article
- Assessment of PTSD in military personnel via machine learning based on physiological habituation in a virtual immersive environment.Scientific reports · 2025Article
- Defining theNature. Mental health · 2024Article
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- What is Common Becomes Normal; Black-White Variation in the Effects of Adversities on Subsequent Initiation of Tobacco and Marijuana During Transitioning into Adolescence.Journal of mental health & clinical psychology · 2024Article
- Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure.Molecular psychiatry · 2023Article
- Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.Biological psychiatry global open science · 2023Article
- Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure.Molecular psychiatry · 2023Article
- Article
- Towards assessing subcortical "deep brain" biomarkers of PTSD with functional near-infrared spectroscopy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity.PLoS genetics · 2023Article
- Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues.Drug and alcohol dependence reports · 2022Article
- Lonely in the Dark: Trauma Memory and Sex-Specific Dysregulation of Amygdala Reactivity to Fear Signals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The structure of PTSD. Development of the Post Traumatic Symptom scale from a clinician-based perspective.European journal of psychotraumatology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAmygdala hyperreactivity to threat has been proposed to be a causal contributor to posttraumatic stress disorder (PTSD). However, emerging literature in healthy samples shows higher test-retest reliability for amygdala habituation (the change over time in response to repeated stimuli) than for its reactivity to threat. Amygdala habituation has received relatively little attention in relationship to PTSD, despite the key role of this region in the etiology of the disorder. Thus, we investigated habituation to repeated fearful face stimuli and PTSD, in a large sample of trauma exposed African American women.
methodsAfrican American women (N = 100) were recruited from a nonprofit hospital serving a largely low-income population with a high risk of trauma exposure. Participants underwent functional magnetic resonance imaging, passively viewing fearful and neutral face stimuli, and reported their history of trauma exposure and current PTSD symptoms. We examined associations between PTSD symptom severity and amygdala reactivity (fearful > neutral) and habituation (early > late) to fearful faces. Secondary analyses tested whether amygdala habituation to fearful faces mediated the association between childhood trauma and PTSD.
resultsPTSD symptom severity and PTSD status (based on self-report measure) were both positively associated with amygdala habituation to repeated fearful face stimuli. Whole-brain analysis showed that this association extended to the bilateral hippocampus and left fusiform gyrus. The association held when controlling for trauma history and depressive symptoms. Amygdala habituation to fearful faces partially mediated the association between childhood trauma severity and PTSD symptom severity.
conclusionIndividuals with greater PTSD symptom severity showed greater amygdala habituation to social threat cues (fearful faces), and greater habituation may partly explain the association between childhood trauma exposure and current PTSD symptoms. Further examination of the dynamics of the amygdala response to threat cues may lead to new insights in the understanding and treatment of stress-related disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.