ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Emergence and Transmission of Drug-/Multidrug-resistant Mycobacterium leprae in a Former Leprosy Colony in the Brazilian Amazon.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Leprosy relapse after multidrug therapy: Systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- On the usage of artificial intelligence in leprosy care: A systematic literature review.PLoS computational biology · 2025Pooled it
- Drug Resistance (Dapsone, Rifampicin, Ofloxacin) and Resistance-Related Gene Mutation Features in Leprosy Patients: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Therapeutic failure of multidrug therapy for leprosy: A retrospective case series in a hyperendemic Brazilian City.PLoS neglected tropical diseases · 2025Article
- Global disease and economic burden of main mycobacterial infections in the working-age population from 1990 to 2021 with a forecast to 2045.Infectious medicine · 2025Article
- Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.Antimicrobial agents and chemotherapy · 2025Article
- Insights into leprosy epidemiology from an isolated population located in the Brazilian Amazon.Scientific reports · 2025Article
- Computational investigation of the global prevalence of multidrug resistantJournal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Leprosy.Nature reviews. Disease primers · 2024Review
- Role of histopathological, serological and molecular findings for the early diagnosis of treatment failure in leprosy.BMC infectious diseases · 2024Article
- Specialized active leprosy search strategies in an endemic area of the Brazilian Amazon identifies a hypermutatedFrontiers in medicine · 2023Article
- Mycobacterium leprae induces Schwann cell proliferation and migration in a denervated milieu following intracutaneous excision axotomy in nine-banded armadillos.Experimental neurology · 2022Article
- Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan.Antimicrobial agents and chemotherapy · 2022Article
- Deep resequencing identifies candidate functional genes in leprosy GWAS loci.PLoS neglected tropical diseases · 2021Article
- Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.Scientific reports · 2020Article
- Leprosy piRnome: exploring new possibilities for an old disease.Scientific reports · 2020Article
- Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment.Antimicrobial agents and chemotherapy · 2020Article
- Case Report: Multidrug-ResistantThe American journal of tropical medicine and hygiene · 2020Article
- Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors.Frontiers in immunology · 2020Article
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23 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLeprosy has been treated with multidrug therapy, which has been distributed for free across the globe and regarded as highly efficient. However, the impossibility of growing Mycobacterium leprae in axenic media has historically impaired assessments of M. leprae resistance, a parameter only recently detectable through molecular methods.
methodsA systematic, population-based search for M. leprae resistance in suspected leprosy relapse cases and contacts was performed in Prata Village, an isolated, hyperendemic, former leprosy colony located in the Brazilian Amazon. Results led to an extended active search involving the entire Prata population. Confirmed leprosy cases were investigated for bacterial resistance using a combination of in vivo testing and direct sequencing of resistance genes folP1, rpoB, and gyrA. A molecular epidemiology analysis was performed using data from 17 variable number tandem repeats (VNTR).
resultsMycobacterium leprae was obtained from biopsies of 37 leprosy cases (18 relapses and 19 new cases): 16 (43.24%) displayed drug-resistance variants. Multidrug resistance to rifampicin and dapsone was observed in 8 relapses and 4 new cases. Single resistance to rifampicin was detected in 1 new case. Resistance to dapsone was present in 2 relapses and 1 new case. Combined molecular resistance and VNTR data revealed evidence of intra-familial primary transmission of resistant M. leprae.
conclusionsA comprehensive, population-based systematic approach to investigate M. leprae resistance in a unique population revealed an alarming scenario of the emergence and transmission of resistant strains. These findings may be used for the development of new strategies for surveillance of drug resistance in other populations.
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