Evidence map›Paper›PMID 31260318›Full record

ArticleJournal of proteome research2019

Proteomics INTegrator (PINT): An Online Tool To Store, Query, and Visualize Large Proteomics Experiment Results.

Salvador Martínez-Bartolomé, Tom Casimir Bamberger, Mathieu Lavallée-Adam, Daniel B McClatchy, John R Yates

Abstract read
In one paragraph

Article in Journal of proteome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Salvador Martínez-BartoloméDepartment of Molecular Medicine , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California , 92037 , United States.ORCID 0000-0001-7592-5612
Tom Casimir BambergerDepartment of Molecular Medicine , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California , 92037 , United States.ORCID 0000-0002-3830-4486
Mathieu Lavallée-AdamDepartment of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology , University of Ottawa , 451 Smyth Road , Ottawa , Ontario K1H 8M5 , Canada.ORCID 0000-0003-2124-3872
Daniel B McClatchyDepartment of Molecular Medicine , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California , 92037 , United States.ORCID 0000-0002-0288-5645
John R YatesDepartment of Molecular Medicine , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California , 92037 , United States.ORCID 0000-0001-5267-1672

Funding

TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
TRAININGU54GM114833 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LINDSEY, MERRY L., PING, PEIPEI · 2014 to 2017
$13.8M
Quantitative Proteome Analysis of Brain DevelopmentR01MH067880 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2003 to 2017
$7.1M
Measurement of Aberrant Protein Folds in Malignant Cells with Proteomics and Mass SpectrometryR33CA212973 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2017 to 2019
$1.2M
NCI NIH HHS R33 CA212973NIGMS NIH HHS P41 GM103533NIGMS NIH HHS U54 GM114833NIMH NIH HHS R01 MH067880
6 · The paper itself

Abstract

The characterization of complex biological systems based on high-throughput protein quantification through mass spectrometry commonly involves differential expression analysis between replicate samples originating from different experimental conditions. Here we present Proteomics INTegrator (PINT), a new user-friendly Web-based platform-independent system to store, visualize, and query proteomics experiment results. PINT provides an extremely flexible query interface that allows advanced Boolean algebra-based data filtering of many different proteomics features such as confidence values, abundance levels or ratios, data set overlaps, sample characteristics, as well as UniProtKB annotations, which are transparently incorporated into the system. In addition, PINT allows developers to incorporate data visualization and analysis tools, such as PSEA-Quant and Reactome pathway analysis, for data set enrichment analysis. PINT serves as a centralized hub for large-scale proteomics data and as a platform for data analysis, facilitating the interpretation of proteomics results and expediting biologically relevant conclusions.

Indexed as

SoftwareDatabases, ProteinHumansInternetMass SpectrometryProteinsProteomicsUser-Computer InterfaceProteinsdata filteringdata querydata visualizationenrichment analysisJava GWTmass spectrometryproteomics

Identifiers

PMID31260318
PMCPMC8278777

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.