Evidence map›Paper›PMID 31260147›Full record

ArticleStem cells (Dayton, Ohio)2019

CD166 Engagement Augments Mouse and Human Hematopoietic Progenitor Function via Activation of Stemness and Cell Cycle Pathways.

Jing Zhang, Joydeep Ghosh, Safa F Mohamad, Chi Zhang, Xinxin Huang, Maegan L Capitano, Andrea M Gunawan, Scott Cooper, Bin Guo, Qingchun Cai and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 4 countries.

Jing ZhangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Joydeep GhoshDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Safa F MohamadDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Chi ZhangDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Xinxin HuangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Maegan L CapitanoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Andrea M GunawanDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Scott CooperDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Bin GuoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Qingchun CaiDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hal E BroxmeyerDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Edward F SrourDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-6026-6498
Indiana University School of MedicineChinese Mathematical Society · CN

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORSR01HL056416 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI BROXMEYER, HAL E. · 1996 to 2017
$6.0M
Enhancing Engraftment of Cord Blood by CD26 InhibitionR01HL112669 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., FARAG, SHERIF S · 2012 to 2016
$3.6M
DEK Regulation of Hematopoietic Stem Cell Renewal, Fate, and HematopoiesisR01DK109188 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., MARKOVITZ, DAVID MICHAEL · 2016 to 2019
$2.0M
National Institutes of Health (NIH) 1S10D012270NCI NIH HHS P30 CA082709NHLBI NIH HHS R01 HL056416NHLBI NIH HHS R01 HL112669NIDDK NIH HHS R01 DK109188NIDDK NIH HHS U54 DK106846NIH HHS R01 HL056416
6 · The paper itself

Abstract

Hematopoietic stem (HSC) and progenitor (HPC) cells are regulated by interacting signals and cellular and noncellular elements of the hematopoietic niche. We previously showed that CD166 is a functional marker of murine and human HSC and of cellular components of the murine niche. Selection of murine CD166

Indexed as

Activated-Leukocyte Cell Adhesion MoleculeAnimalsAntigens, CDCell Adhesion Molecules, NeuronalCell CycleFetal ProteinsHematopoiesisHematopoietic Stem CellsHumansMiceActivated-Leukocyte Cell Adhesion MoleculeALCAM protein, humanAntigens, CDCell Adhesion Molecules, NeuronalFetal ProteinsCD166Hematopoietic stem and progenitor cellsHomophilic interactionSingle-cell RNA-seq analysis

Identifiers

PMID31260147
PMCPMC9274619
OpenAlexW2953570135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.