Evidence map›Paper›PMID 31259853›Full record

ArticleSexually transmitted diseases2019

Lack of Association Between the S83I ParC Mutation in Mycoplasma genitalium and Treatment Outcomes Among Men Who Have Sex With Men with Nongonococcal Urethritis.

Laura C Chambers, Jørgen S Jensen, Jennifer L Morgan, M Sylvan Lowens, Sarah S Romano, Patricia A Totten, Olusegun O Soge, James P Hughes, Matthew R Golden, Lisa E Manhart

Open access · greenAbstract read
In one paragraph

Article in Sexually transmitted diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  2. Article
  3. Mycoplasma genitalium in the US (MyGeniUS): Surveillance Data From Sexual Health Clinics in 4 US Regions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  4. Article
  5. High Rates of AsymptomaticOpen forum infectious diseases · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Laura C ChambersFrom the Department of Epidemiology, University of Washington, Seattle, WA.
Jørgen S JensenStatens Serum Institut, Copenhagen, Denmark.
Jennifer L MorganHIV/STD Program, Public Health-Seattle and King County.
M Sylvan LowensHIV/STD Program, Public Health-Seattle and King County.
Sarah S RomanoFrom the Department of Epidemiology, University of Washington, Seattle, WA.
Patricia A TottenDepartment of Medicine.
Olusegun O SogeDepartment of Medicine.
James P HughesDepartment of Biostatistics, University of Washington, Seattle, WA.
Matthew R GoldenFrom the Department of Epidemiology, University of Washington, Seattle, WA.
Lisa E ManhartFrom the Department of Epidemiology, University of Washington, Seattle, WA.
University of Washington · USPublic Health – Seattle & King County · USStatens Serum Institut · DK

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Urethral microbiome and non-gonococcal urethritis in men who have sex with men (MU19AI113173 · NIAID · UNIVERSITY OF WASHINGTON · PI MARRAZZO, JEANNE M · 2014 to 2018
$14.3M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
NCATS NIH HHS TL1 TR002318NCATS NIH HHS UL1 TR002319NIAID NIH HHS U19 AI113173
6 · The paper itself

Abstract

From February 2015 to October 2017, among 20 men who have sex with men with Mycoplasma genitalium-associated nongonococcal urethritis, 15% had macrolide resistance and S83I ParC mutations. Azithromycin followed by moxifloxacin cleared Mycoplasma genitalium in 2 of 2 with and 11 of 13 without S83I mutations. Dual failures were cleared after doxycycline. S83I mutations were not associated with moxifloxacin failure.

Indexed as

Homosexuality, MaleAdultAnti-Bacterial AgentsDNA Topoisomerase IVDrug Resistance, BacterialHumansMaleMycoplasma genitaliumMycoplasma InfectionsSexual and Gender MinoritiesTreatment OutcomeUrethritisAnti-Bacterial AgentsDNA Topoisomerase IV

Identifiers

PMID31259853
PMCPMC7011110
OpenAlexW2956049546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.