ArticleJournal of the Chinese Medical Association : JCMA2019
Adipose-derived stem cells-induced burn wound healing and regeneration of skin appendages in a novel skin island rat model.
Article in Journal of the Chinese Medical Association : JCMA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The efficacy of adipose-derived stem cells in burn injuries: a systematic review.Cellular & molecular biology letters · 2024Pooled it
- Effect of stem cell treatment on burn wounds: A systemic review and a meta-analysis.International wound journal · 2023Pooled it
- Effectiveness of the adipose stem cells in burn wound healing: literature review.Cell and tissue banking · 2022Pooled it
- Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies.Stem cell research & therapy · 2020Pooled it
- Plasma-rich fibrin gel and adipose-derived allogeneic mesenchymal stem cells: innovation in the treatment of second-degree deep burn wound; characterization and in-vivo study.Cell and tissue banking · 2025Article
- Insights into the role of mesenchymal stem cells in cutaneous medical aesthetics: from basics to clinics.Stem cell research & therapy · 2024Review
- Latest advance anti-inflammatory hydrogel wound dressings and traditionalFrontiers in bioengineering and biotechnology · 2024Review
- The emerging progress on wound dressings and their application in clinic wound management.Heliyon · 2023Review
- Application of Adipose-Tissue Derived Products for Burn Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications.International journal of molecular sciences · 2023Review
- Chorioallantoic Membrane Assay at the Cross-Roads of Adipose-Tissue-Derived Stem Cell Research.Cells · 2023Review
- Functional drug-delivery hydrogels for oral and maxillofacial wound healing.Frontiers in bioengineering and biotechnology · 2023Review
- Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds.European burn journal · 2022Review
- Review
- Erratum.Journal of the Chinese Medical Association : JCMA · 2022Article
- Recent Advances in Experimental Burn Models.Biology · 2021Review
- Uric acid in diabetic nephropathy.Journal of the Chinese Medical Association : JCMA · 2020Article
- Predictors in major burn patients.Journal of the Chinese Medical Association : JCMA · 2020Article
- Mesenchymal stem cells and cerebral palsy.Journal of the Chinese Medical Association : JCMA · 2020Article
- Mesenchymal stem cells-derived magic bullets for burns.Journal of the Chinese Medical Association : JCMA · 2020Article
Corrections and comments
- Commented on by
- Erratum issuedErratum.2022
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study of effectiveness of adipose-derived stem cells (ASCs) in treating burn wounds is still a developing field. The process of wound contraction in areas of loose skin is a major confounding factor in the evaluation and study of burn wound healing in animal models.
methodsTo evaluate the effect of local ASCs administration, deep partial thickness burn wounds were induced by 30 s application of hot copper plates in a novel skin island burn wound rat model to avoid interference from primary wound contraction. Skin islands were divided into two treatment groups-control group (n = 9) injected with PBS and ASCs-treated group (n = 9) injected with 5 × 10 ASCs intradermally. Progress in wound healing was checked at regular intervals after injury (on 1st, 2nd, 3rd, and 4th week) by measuring the mean wound area and analyzing the wound histologically and immunohistochemically, after unstitching the overlaying skin to expose the skin island.
resultsIt was found that local intradermal injection of ASCs improved burn wound healing at all given time points when compared with control groups, especially in the first 2 weeks (p < 0.05). The percentage of live follicles increased gradually in the ASCs-treated groups compared with control groups between the 3rd and 4th weeks (p < 0.05). The vascular density and proliferating cell nuclear antigen index were also significantly increased in the ASCs-treated groups.
conclusionThus, in this study, a novel burn wound rat model with reduced interference from wound contraction has been put forth to investigate the therapeutic effects of local administration of ASCs on burn wound healing. Local injection of ASCs not only improved burn wound recovery but also enhanced angiogenesis and skin appendage regeneration.
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