Evidence map›Paper›PMID 31259519›Full record

ArticleACS chemical biology2019

Interstrand DNA Cross-Links Derived from Reaction of a 2-Aminopurine Residue with an Abasic Site.

Maryam Imani Nejad, Nathan E Price, Tuhin Haldar, Calvin Lewis, Yinsheng Wang, Kent S Gates

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maryam Imani NejadDepartment of Chemistry , University of Missouri , 125 Chemistry Building , Columbia , Missouri 65211 , United States.
Nathan E PriceDepartment of Chemistry , University of California Riverside , Riverside , California 92521-0403 , United States.
Tuhin HaldarDepartment of Chemistry , University of Missouri , 125 Chemistry Building , Columbia , Missouri 65211 , United States.
Calvin LewisDepartment of Chemistry , University of Missouri , 125 Chemistry Building , Columbia , Missouri 65211 , United States.
Yinsheng WangDepartment of Chemistry , University of California Riverside , Riverside , California 92521-0403 , United States.
Kent S GatesDepartment of Chemistry , University of Missouri , 125 Chemistry Building , Columbia , Missouri 65211 , United States.ORCID 0000-0002-4218-7411
University of Missouri · USUniversity of California, Riverside · US

Funding

Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
Cross-links At Abasic Sites in Duplex DNAR01ES021007 · NIEHS · UNIVERSITY OF MISSOURI-COLUMBIA · PI GATES, KENT S, WANG, YINSHENG · 2012 to 2023
$3.7M
NIEHS NIH HHS R01 ES021007NIEHS NIH HHS T32 ES018827
6 · The paper itself

Abstract

Efficient methods for the site-specific installation of structurally defined interstrand cross-links in duplex DNA may be useful in a wide variety of fields. The work described here developed a high-yield synthesis of chemically stable interstrand cross-links resulting from a reductive amination reaction between an abasic site and the noncanonical nucleobase 2-aminopurine in duplex DNA. Results from footprinting, liquid chromatography-mass spectrometry, and stability studies support the formation of an

Indexed as

2-AminopurineAminationCross-Linking ReagentsDNAModels, MolecularNucleic Acid ConformationNucleic Acid DenaturationOxidation-Reduction2-AminopurineCross-Linking ReagentsDNA

Identifiers

PMID31259519
PMCPMC8667195
OpenAlexW2948802933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.