ArticleAmerican journal of hematology2019
Anemia predicts lower white matter volume and cognitive performance in sickle and non-sickle cell anemia syndrome.
Article in American journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 43 citations in OpenAlex.
- Mind the Gut: Cognitive Decline, Microbiota, and Nutrition-Related Modulators in Older Adults with Chronic Kidney Disease.Nutrients · 2026Review
- Heme-mediated Tau phosphorylation drives neurocognitive responses in sickle cell disease.Blood red cells & iron · 2026Article
- Regional brain age is decreased in children with sickle cell anemia.Blood advances · 2026Article
- Female predominance in nocturnal hypoxemia among elderly OSAS patients: hemoglobin mediates sex-specific hypoxic burden in Chinese cohorts.BMC geriatrics · 2025Article
- Association between hemoglobin levels and cerebral white matter volume in a general older Japanese population: the Iki-Iki study.Neuroradiology · 2025Article
- Exploring Posturography in Children with Sickle Cell Disease.Physical & occupational therapy in pediatrics · 2025Article
- Cerebral Oxygen Metabolic Stress in Children and Adults With Large Vessel Vasculopathy Due to Sickle Cell Disease.Neurology · 2024Article
- Brain perfusion changes in beta-thalassemia.Orphanet journal of rare diseases · 2024Article
- Neurocognitive outcome in children with sickle cell disease after myeloimmunoablative conditioning and haploidentical hematopoietic stem cell transplantation: a non-randomized clinical trial.Frontiers in neurology · 2024Article
- Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia.British journal of haematology · 2023Article
- Brain Volumes and Cognition in Patients with Sickle Cell Anaemia: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Brain BOLD and NIRS response to hyperoxic challenge in sickle cell disease and chronic anemias.Magnetic resonance imaging · 2023Article
- Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia.Blood advances · 2023Article
- "Severe Anemia: A Case Report of an Uncommon Precipitant of Schizophrenia Relapse".Journal of blood medicine · 2023Article
- Silent infarction in sickle cell disease is associated with brain volume loss in excess of infarct volume.Frontiers in neurology · 2023Article
- Effects of regional brain volumes on cognition in sickle cell anemia: A developmental perspective.Frontiers in neurology · 2023Article
- Neurodevelopmental Outcomes in Preterm Children with Sickle Cell Disease.Journal of the International Neuropsychological Society : JINS · 2022Article
- Cerebral oxygen metabolic stress is increased in children with sickle cell anemia compared to anemic controls.American journal of hematology · 2022Article
- Sickle cell cerebrovascular reactivity to a COFrontiers in physiology · 2022Article
- Erythrocytes Are an Independent Protective Factor for Vascular Cognitive Impairment in Patients With Severe White Matter Hyperintensities.Frontiers in aging neuroscience · 2022Article
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Abstract
Severe chronic anemia is an independent predictor of overt stroke, white matter damage, and cognitive dysfunction in the elderly. Severe anemia also predisposes to white matter strokes in young children, independent of the anemia subtype. We previously demonstrated symmetrically decreased white matter (WM) volumes in patients with sickle cell disease (SCD). In the current study, we investigated whether patients with non-sickle anemia also have lower WM volumes and cognitive dysfunction. Magnetic Resonance Imaging was performed on 52 clinically asymptomatic SCD patients (age = 21.4 ± 7.7; F = 27, M = 25; hemoglobin = 9.6 ± 1.6 g/dL), 26 non-sickle anemic patients (age = 23.9 ± 7.9; F = 14, M = 12; hemoglobin = 10.8 ± 2.5 g/dL) and 40 control subjects (age = 27.7 ± 11.3; F = 28, M = 12; hemoglobin = 13.4 ± 1.3 g/dL). Voxel-wise changes in WM brain volumes were compared to hemoglobin levels to identify brain regions that are vulnerable to anemia. White matter volume was diffusely lower in deep, watershed areas proportionally to anemia severity. After controlling for age, sex, and hemoglobin level, brain volumes were independent of disease. WM volume loss was associated with lower Full Scale Intelligence Quotient (FSIQ; P = .0048; r
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